Current understanding of the molecular and cellular pathology of diabetic retinopathy

DA Antonetti, PS Silva, AW Stitt - Nature Reviews Endocrinology, 2021 - nature.com
Diabetes mellitus has profound effects on multiple organ systems; however, the loss of
vision caused by diabetic retinopathy might be one of the most impactful in a patient's life …

Therapeutic potential of endothelial colony-forming cells in ischemic disease: strategies to improve their regenerative efficacy

P Faris, S Negri, A Perna, V Rosti, G Guerra… - International journal of …, 2020 - mdpi.com
Cardiovascular disease (CVD) comprises a range of major clinical cardiac and circulatory
diseases, which produce immense health and economic burdens worldwide. Currently …

[HTML][HTML] Mesenchymal stem cell-derived extracellular vesicles as a new therapeutic strategy for ocular diseases

B Yu, XR Li, XM Zhang - World journal of stem cells, 2020 - ncbi.nlm.nih.gov
Mesenchymal stem cells (MSCs) have attracted considerable attention for their activity in the
treatment of refractory visual disorders. Since MSCs were found to possess the beneficial …

Advances in cell therapies using stem cells/progenitors as a novel approach for neurovascular repair of the diabetic retina

J Lechner, RJ Medina, N Lois, AW Stitt - Stem Cell Research & Therapy, 2022 - Springer
Background Diabetic retinopathy, a major complication of diabetes mellitus, is a leading
cause of sigh-loss in working age adults. Progressive loss of integrity of the retinal …

Modulation of mesenchymal stem cells for enhanced therapeutic utility in ischemic vascular diseases

SL Elshaer, SH Bahram, P Rajashekar… - International Journal of …, 2021 - mdpi.com
Mesenchymal stem cells are multipotent stem cells isolated from various tissue sources,
including but not limited to bone marrow, adipose, umbilical cord, and Wharton Jelly …

Mesenchymal stromal cells promote retinal vascular repair by modulating Sema3E and IL-17A in a model of ischemic retinopathy

B Noueihed, JC Rivera, R Dabouz, P Abram… - Frontiers in cell and …, 2021 - frontiersin.org
Ischemic retinopathies (IRs), such as retinopathy of prematurity and diabetic retinopathy, are
characterized by an initial phase of microvascular degeneration that results in retinal …

Mesenchymal stem cell induced Foxp3 (+) Tregs suppress effector T cells and protect against retinal ischemic injury

M Agrawal, PK Rasiah, A Bajwa, J Rajasingh… - Cells, 2021 - mdpi.com
Mesenchymal stem/stromal cells (MSC) are well known for immunomodulation; however, the
mechanisms involved in their benefits in the ischemic retina are unknown. This study tested …

Ranibizumab for the treatment of retinopathy of prematurity: systematic review and meta-analysis

N Alva, AR Martínez, B Ortiz-Saavedra… - Frontiers in …, 2023 - frontiersin.org
Anti-VEGF drugs like ranibizumab can be used to treat retinopathy of prematurity (ROP) by
halting the formation of abnormal blood vessels, or lasers can be used to burn the edges of …

[PDF][PDF] Мультикомпонентный подход к диагностике изменений сетчатки при артериальной гипертензии

А ДИАГНОСТИКАСИГА, КЎПК ЁНДАШУВ - Биология, 2021 - pbim.uz
Ушбу мақолада дунёнинг турли мамлакатларидан келган олимлар томонидан arterial
гипертензия (АҲ) нинг retinal ўзгаришларини ташхислаш муаммосининг ечимини кўриб …

R-Ras deficiency in pericytes causes frequent microphthalmia and perturbs retinal vascular development

JL Herrera, M Komatsu - Journal of vascular research, 2021 - karger.com
Purpose: The retinal vasculature is heavily invested by pericytes. Small GTPase R-Ras is
highly expressed in endothelial cells and pericytes, suggesting importance of this Ras …