A guide to the organ-on-a-chip

CM Leung, P De Haan… - Nature Reviews …, 2022‏ - nature.com
Abstract Organs-on-chips (OoCs) are systems containing engineered or natural miniature
tissues grown inside microfluidic chips. To better mimic human physiology, the chips are …

A role for microfluidic systems in precision medicine

JM Ayuso, M Virumbrales-Muñoz, JM Lang… - Nature …, 2022‏ - nature.com
Precision oncology continues to challenge the “one-size-fits-all” dogma. Under the precision
oncology banner, cancer patients are screened for molecular tumor alterations that predict …

Nanotechnology for a sustainable future: Addressing global challenges with the international network4sustainable nanotechnology

L Pokrajac, A Abbas, W Chrzanowski, GM Dias… - 2021‏ - ACS Publications
Nanotechnology has important roles to play in international efforts in sustainability. We
discuss how current and future capabilities in nanotechnology align with and support the …

Fabrication methods for microfluidic devices: An overview

SM Scott, Z Ali - Micromachines, 2021‏ - mdpi.com
Microfluidic devices offer the potential to automate a wide variety of chemical and biological
operations that are applicable for diagnostic and therapeutic operations with higher …

Organ-on-a-chip: a new paradigm for drug development

C Ma, Y Peng, H Li, W Chen - Trends in pharmacological sciences, 2021‏ - cell.com
The pharmaceutical industry has been desperately searching for efficient drug discovery
methods. Organ-on-a-Chip, a cutting-edge technology that can emulate the physiological …

[HTML][HTML] Biofabrication methods for reconstructing extracellular matrix mimetics

A Aazmi, D Zhang, C Mazzaglia, M Yu, Z Wang… - Bioactive Materials, 2024‏ - Elsevier
In the human body, almost all cells interact with extracellular matrices (ECMs), which have
tissue and organ-specific compositions and architectures. These ECMs not only function as …

Tumor-on-a-chip: from bioinspired design to biomedical application

X Liu, J Fang, S Huang, X Wu, X **e, J Wang… - Microsystems & …, 2021‏ - nature.com
Cancer is one of the leading causes of human death, despite enormous efforts to explore
cancer biology and develop anticancer therapies. The main challenges in cancer research …

Current challenges of iPSC-based disease modeling and therapeutic implications

MX Doss, A Sachinidis - Cells, 2019‏ - mdpi.com
Induced pluripotent stem cell (iPSC)-based disease modelling and the cell replacement
therapy approach have proven to be very powerful and instrumental in biomedical research …

Organ-on-a-chip: a survey of technical results and problems

AE Danku, EH Dulf, C Braicu, A Jurj… - … in bioengineering and …, 2022‏ - frontiersin.org
Organ-on-a-chip (OoC), also known as micro physiological systems or “tissue chips” have
attracted substantial interest in recent years due to their numerous applications, especially in …

Microfluidic organ-on-chip system for multi-analyte monitoring of metabolites in 3D cell cultures

J Dornhof, J Kieninger, H Muralidharan, J Maurer… - Lab on a Chip, 2022‏ - pubs.rsc.org
Three-dimensional cell cultures using patient-derived stem cells are essential in vitro
models for a more efficient and individualized cancer therapy. Currently, culture conditions …