Epidemiological studies have provided compelling evidence that multiple sclerosis (MS) is a
rare complication of infection with the Epstein–Barr virus (EBV), a herpesvirus that infects …

Epstein–Barr virus (EBV) is a ubiquitous human lymphotropic herpesvirus with a well-
established causal role in several cancers. Recent studies have provided compelling …

Multiple sclerosis (MS) is a chronic inflammatory and degenerative disease of the central
nervous system afflicting nearly three million individuals worldwide. Neuroimmune …

Multiple sclerosis (MS) is an inflammatory disease of the central nervous system, for which
Epstein-Barr virus (EBV) infection is a likely prerequisite. Due to the homology between …

Specific microbial signals induce the differentiation of a distinct pool of RORγ+ regulatory T
(Treg) cells crucial for intestinal homeostasis. We discovered highly analogous populations …

Inflammation is an integral part of autoimmune diseases, which are caused by dysregulation
of the immune system. This dysregulation involves an imbalance between pro-inflammatory …

Molecular mimicry is one of the leading mechanisms by which infectious or chemical agents
may induce autoimmunity. It occurs when similarities between foreign and self-peptides …

Fifty years since the first description of an association between HLA and human disease,
HLA molecules have proven to be central to physiology, protective immunity and …

Multiple sclerosis is an autoimmune disease that is caused by the interplay of genetic,
particularly the HLA-DR15 haplotype, and environmental risk factors. How these etiologic …

Th17 cells provide protection at barrier tissues but may also contribute to immune pathology.
The relevance and induction mechanisms of pathologic Th17 responses in humans are …