The development of the vertebrate eyes is a complex process starting from anterior-posterior
and dorso-ventral patterning of the anterior neural tube, resulting in the formation of the eye …

Retinal neurodegeneration associated with the dysfunction or death of photoreceptors is a
major cause of incurable vision loss. Tremendous progress has been made over the last two …

The retinal pigment epithelium (RPE) is a simple epithelium interposed between the neural
retina and the choroid. Although only 1 cell-layer in thickness, the RPE is a virtual …

Age related macular degeneration (AMD) is a complex multifactorial disease caused by the
interplay of age and genetic and environmental risk factors. A common feature observed in …

The identity of specific cell types in the nervous system is defined by the expression of
neuron type–specific gene batteries. How the expression of such batteries is initiated during …

Dysfunction and loss of the retinal pigment epithelium (RPE) are hallmarks of retinal
degenerative diseases in mammals. A critical transcription factor for RPE development and …

Adult zebrafish possess the remarkable capacity to regenerate neurons. In the damaged
zebrafish retina, Müller glia reprogram and divide to produce neuronal progenitor cells …

Abstract The Southern catfish (Silurus meridionalis) is a nocturnal and benthic freshwater
fish endemic to the Yangtze River and its tributaries. In this study, we constructed a …

Many transcription factors regulating the production, survival, and function of photoreceptor
cells have been identified, but little is known about transcriptional co-regulators in retinal …

The homeoprotein family comprises~ 300 transcription factors and was long seen as
primarily involved in developmental programs through cell autonomous regulation …