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Genetics of azoospermia
Azoospermia affects 1% of men, and it can be due to:(i) hypothalamic-pituitary
dysfunction,(ii) primary quantitative spermatogenic disturbances,(iii) urogenital duct …
dysfunction,(ii) primary quantitative spermatogenic disturbances,(iii) urogenital duct …
Human aneuploidy: mechanisms and new insights into an age-old problem
SI Nagaoka, TJ Hassold, PA Hunt - Nature Reviews Genetics, 2012 - nature.com
Trisomic and monosomic (aneuploid) embryos account for at least 10% of human
pregnancies and, for women nearing the end of their reproductive lifespan, the incidence …
pregnancies and, for women nearing the end of their reproductive lifespan, the incidence …
Single-cell RNA sequencing of human, macaque, and mouse testes uncovers conserved and divergent features of mammalian spermatogenesis
Spermatogenesis is a highly regulated process that produces sperm to transmit genetic
information to the next generation. Although extensively studied in mice, our current …
information to the next generation. Although extensively studied in mice, our current …
Male gametes are generated through a specialised differentiation pathway involving a
series of developmental transitions that are poorly characterised at the molecular level …
series of developmental transitions that are poorly characterised at the molecular level …
Transgenerational epigenetic inheritance: prevalence, mechanisms, and implications for the study of heredity and evolution
This review describes new developments in the study of transgenerational epigenetic
inheritance, a component of epigenetics. We start by examining the basic concepts of the …
inheritance, a component of epigenetics. We start by examining the basic concepts of the …
The advantages and disadvantages of being polyploid
L Comai - Nature reviews genetics, 2005 - nature.com
Polyploids—organisms that have multiple sets of chromosomes—are common in certain
plant and animal taxa, and can be surprisingly stable. The evidence that has emerged from …
plant and animal taxa, and can be surprisingly stable. The evidence that has emerged from …
The TopoVIB-Like protein family is required for meiotic DNA double-strand break formation
T Robert, A Nore, C Brun, C Maffre, B Crimi, V Guichard… - Science, 2016 - science.org
Meiotic recombination is induced by the formation of DNA double-strand breaks (DSBs)
catalyzed by SPO11, the ortholog of subunit A of TopoVI DNA topoisomerase (TopoVIA) …
catalyzed by SPO11, the ortholog of subunit A of TopoVI DNA topoisomerase (TopoVIA) …
Histone variants—ancient wrap artists of the epigenome
Histones wrap DNA to form nucleosome particles that compact eukaryotic genomes. Variant
histones have evolved crucial roles in chromosome segregation, transcriptional regulation …
histones have evolved crucial roles in chromosome segregation, transcriptional regulation …
MIWI2 is essential for spermatogenesis and repression of transposons in the mouse male germline
MA Carmell, A Girard, HJG Van De Kant, D Bourc'his… - Developmental cell, 2007 - cell.com
Summary Small RNAs associate with Argonaute proteins and serve as sequence-specific
guides for regulation of mRNA stability, productive translation, chromatin organization, and …
guides for regulation of mRNA stability, productive translation, chromatin organization, and …
Genetics of mammalian meiosis: regulation, dynamics and impact on fertility
MA Handel, JC Schimenti - Nature Reviews Genetics, 2010 - nature.com
Meiosis is an essential stage in gamete formation in all sexually reproducing organisms.
Studies of mutations in model organisms and of human haplotype patterns are leading to a …
Studies of mutations in model organisms and of human haplotype patterns are leading to a …