Eukaryotic cilia and flagella are evolutionarily conserved organelles that protrude from the
cell surface. The unique location and properties of cilia allow them to function in vital …

The cilium is a complex organelle, the assembly of which requires the coordination of motor-
driven intraflagellar transport (IFT), membrane trafficking and selective import of cilium …

Anterograde intraflagellar transport (IFT) trains are essential for cilia assembly and
maintenance. These trains are formed of 22 IFT-A and IFT-B proteins that link structural and …

The centrosome is the primary microtubule organizing center of the cells and templates the
formation of cilia, thereby operating at a nexus of critical cellular functions. Here, we use …

Cilia are plasma membrane protrusions that act as cellular propellers or antennae. To
perform these functions, cilia must maintain a composition distinct from those of the …

Chlamydomonas reinhardtii is a unicellular green alga whose lineage diverged from land
plants over 1 billion years ago. It is a model system for studying chloroplast-based …

Defects in the function of cellular organelles such as peroxisomes, lysosomes and
mitochondria are well-known causes of human diseases. Recently, another organelle has …

Cilia are membrane-bounded, centriole-derived projections from the cell surface that contain
a microtubule cytoskeleton, the ciliary axoneme, surrounded by a ciliary membrane …

In motile cilia, a mechanoregulatory network is responsible for converting the action of
thousands of dynein motors bound to doublet microtubules into a single propulsive …

The cilium is a large macromolecular machine that is vital for motility, signaling, and sensing
in most eukaryotic cells. Its conserved core structure, the axoneme, contains nine …