Glioblastoma (GBM) is the most deadly type of malignant brain tumor, despite extensive
molecular analyses of GBM cells. In recent years, the tumor microenvironment (TME) has …

Glioblastomas are heterogeneous and invariably lethal tumours. They are characterized by
genetic and epigenetic variations among tumour cells, which makes the development of …

Extracellular vesicles (EVs) are a heterogeneous collection of membrane-bound carriers
with complex cargoes including proteins, lipids, and nucleic acids. While the release of EVs …

The complexity of glioblastoma multiforme, the most common and lethal variant of gliomas,
is reflected by cellular and molecular heterogeneity at both the inter-and intra-tumoural …

Pseudouridine is the most frequent epitranscriptomic modification. However, its cellular
functions remain largely unknown. Here, we show that pseudouridine synthase 7 (PUS7) is …

Extracellular matrix is a complex network of macromolecules that constitute a
microenvironment of normal tissues and malignancies such as the primary brain tumor …

Abstract Interferon Regulatory Factors (IRFs), a family of transcription factors, profoundly
influence the immune system, impacting both physiological and pathological processes …

Glioblastoma is the deadliest form of brain cancer. Aside from inadequate treatment options,
one of the main reasons glioblastoma is so lethal is the rapid growth of tumour cells coupled …

Building on the pyrazolopyrimidine CK2 (casein kinase 2) inhibitor scaffold, we designed a
small targeted library. Through comprehensive evaluation of inhibitor selectivity, we …

Glioblastoma is a highly aggressive brain tumor that is characterized by its unparalleled
invasiveness. Invasive glioblastoma cells not only escape surgery and focal therapies but …