The characteristics, occurrence, and toxicological effects of patulin

I Saleh, I Goktepe - Food and chemical toxicology, 2019‏ - Elsevier
Mycotoxins are the secondary metabolites secreted by different types of fungi to which
humans can get exposed mainly via ingestion. Patulin (C 7 H 6 O 4) is a polyketide lactone …

Structure-toxicity relationships, toxicity mechanisms and health risk assessment of food-borne modified deoxynivalenol and zearalenone: A comprehensive review

Q Lu, JY Luo, HN Ruan, CJ Wang, MH Yang - Science of The Total …, 2022‏ - Elsevier
Mycotoxin, as one of the most common pollutants in foodstuffs, poses great threat to food
security and human health. Specifically, deoxynivalenol (DON) and zearalenone (ZEN) …

Translation attenuation through eIF2α phosphorylation prevents oxidative stress and maintains the differentiated state in β cells

SH Back, D Scheuner, J Han, B Song, M Ribick… - Cell metabolism, 2009‏ - cell.com
Accumulation of unfolded protein within the endoplasmic reticulum (ER) attenuates mRNA
translation through PERK-mediated phosphorylation of eukaryotic initiation factor 2 on …

Patulin induces apoptosis through ROS-mediated endoplasmic reticulum stress pathway

M Boussabbeh, I Ben Salem, A Prola… - Toxicological …, 2015‏ - academic.oup.com
Patulin (PAT) is a toxic metabolite produced by several filamentous fungi of the genera of
Penicillium, Aspergillus, and Byssochlamys. PAT is the most common mycotoxin found in …

Mitochondrially targeted anti-cancer agents

L Biasutto, LF Dong, M Zoratti, J Neuzil - Mitochondrion, 2010‏ - Elsevier
Cancer is an ever-increasing problem that is yet to be harnessed. Frequent mutations make
this pathology very variable and, consequently, a considerable challenge. Intriguingly …

[HTML][HTML] Moringa oleifera Protects SH-SY5YCells from DEHP-Induced Endoplasmic Reticulum Stress and Apoptosis

I Amara, ML Ontario, M Scuto, GM Lo Dico, S Sciuto… - Antioxidants, 2021‏ - mdpi.com
Moringa oleifera (MO) is a medicinal plant that has been shown to possess antioxidant,
anticarcinogenic and antibiotic activities. In a rat model, MO extract (MOe) has been shown …

Silver nanoparticle fate in mammals: Bridging in vitro and in vivo studies

M Marchioni, PH Jouneau, M Chevallet… - Coordination Chemistry …, 2018‏ - Elsevier
Silver nanoparticles (AgNPs) are exponentially used in various consumer products including
medical devices. This production leads to an increasing human exposure to silver in …

[HTML][HTML] Hsp90 inhibition by PU-H71 induces apoptosis through endoplasmic reticulum stress and mitochondrial pathway in cancer cells and overcomes the …

C Gallerne, A Prola, C Lemaire - … et Biophysica Acta (BBA)-Molecular Cell …, 2013‏ - Elsevier
Heat shock protein 90 (Hsp90) has recently emerged as an attractive therapeutic target in
cancer treatment because of its role in stabilizing the active form of a wide range of client …

[HTML][HTML] Crocin and Quercetin protect HCT116 and HEK293 cells from Zearalenone-induced apoptosis by reducing endoplasmic reticulum stress

IB Salem, A Prola, M Boussabbeh, A Guilbert… - Cell Stress and …, 2015‏ - Elsevier
Mycotoxins are considered to be significant contaminants of food and animal feed.
Zearalenone (ZEN) is a non-steroidal estrogenic mycotoxin produced by several species of …

Mitochondrial remodeling in cancer metabolism and survival: potential for new therapies

IA Barbosa, NG Machado, AJ Skildum, PM Scott… - … et Biophysica Acta (BBA …, 2012‏ - Elsevier
Mitochondria are semi-autonomous organelles that play essential roles in cellular
metabolism and programmed cell death pathways. Genomic, functional and structural …