Microtubules are dynamic polymers of αβ-tubulin that form diverse cellular structures, such
as the mitotic spindle for cell division, the backbone of neurons, and axonemes. To control …

The microtubule (MT) cytoskeleton supports a broad range of cellular functions, from
providing tracks for intracellular transport, to supporting movement of cilia and flagella, to …

The kinesin-3 family is one of the largest among the kinesin superfamily and its members
play important roles in a wide range of cellular transport activities, yet the molecular …

Despite the crowdedness of the interior of cells, microtubule-based motor proteins are able
to deliver cargoes rapidly and reliably throughout the cytoplasm. We hypothesize that motor …

During vertebrate mitosis, the centromere-associated kinesin CENP-E (centromere protein
E) transports misaligned chromosomes to the plus ends of spindle microtubules …

Kinesin-5 slides antiparallel microtubules during spindle assembly, and regulates the
branching of growing axons. Besides the mechanical activities enabled by its tetrameric …

Chromosome alignment and biorientation is essential for mitotic progression and genomic
stability. Most chromosomes align at the spindle equator in a motor-independent manner …

Microtubules are major components of the eukaryotic cytoskeleton. Posttranslational
modifications (PTMs) of tubulin regulates interactions with microtubule-associated proteins …

All living organisms must transmit genetic information through successive generations, and
all six eukaryotic supergroups utilize a mitotic spindle to accomplish this task. The mitotic …

The dendritic arbor is subject to continual activity-dependent remodeling, requiring a
balance between directed cargo trafficking and dynamic restructuring of the underlying …