Intermuscular adipose tissue in metabolic disease

BH Goodpaster, BC Bergman, AM Brennan… - Nature Reviews …, 2023 - nature.com
Intermuscular adipose tissue (IMAT) is a distinct adipose depot described in early reports as
a 'fatty replacement'or 'muscle fat infiltration'that was linked to ageing and neuromuscular …

Impaired skeletal muscle regeneration in diabetes: From cellular and molecular mechanisms to novel treatments

E Espino-Gonzalez, E Dalbram, R Mounier, J Gondin… - Cell Metabolism, 2024 - cell.com
Diabetes represents a major public health concern with a considerable impact on human life
and healthcare expenditures. It is now well established that diabetes is characterized by a …

Lipid metabolism in sarcopenia

A Al Saedi, DA Debruin, A Hayes, M Hamrick - Bone, 2022 - Elsevier
Sarcopenia is an age-related disease associated with loss of muscle mass and strength.
This geriatric syndrome predisposes elderly individuals to a disability, falls, fractures, and …

Adipose tissue as a linchpin of organismal ageing

TT Nguyen, S Corvera - Nature Metabolism, 2024 - nature.com
Ageing is a conserved biological process, modulated by intrinsic and extrinsic factors, that
leads to changes in life expectancy. In humans, ageing is characterized by greatly increased …

Evolving roles of muscle-resident fibro-adipogenic progenitors in health, regeneration, neuromuscular disorders, and aging

M Theret, FMV Rossi, O Contreras - Frontiers in Physiology, 2021 - frontiersin.org
Normal skeletal muscle functions are affected following trauma, chronic diseases, inherited
neuromuscular disorders, aging, and cachexia, hampering the daily activities and quality of …

Myosteatosis in cirrhosis: a review of diagnosis, pathophysiological mechanisms and potential interventions

M Ebadi, C Tsien, RA Bhanji, AR Dunichand-Hoedl… - Cells, 2022 - mdpi.com
Myosteatosis, or pathological excess fat accumulation in muscle, has been widely defined
as a lower mean skeletal muscle radiodensity on computed tomography (CT). It is reported …

Searching for the link between inflammaging and sarcopenia

T Wang - Ageing Research Reviews, 2022 - Elsevier
Searching for the link between inflammaging and sarcopenia - ScienceDirect Skip to main
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[HTML][HTML] Fibro-adipogenic progenitors in physiological adipogenesis and intermuscular adipose tissue remodeling

M Flores-Opazo, D Kopinke, F Helmbacher… - Molecular aspects of …, 2024 - Elsevier
Excessive accumulation of intermuscular adipose tissue (IMAT) is a common pathological
feature in various metabolic and health conditions and can cause muscle atrophy, reduced …

[HTML][HTML] Factors of muscle quality and determinants of muscle strength: a systematic literature review

LB Kuschel, D Sonnenburg, T Engel - Healthcare, 2022 - mdpi.com
Muscle quality defined as the ratio of muscle strength to muscle mass disregards underlying
factors which influence muscle strength. The aim of this review was to investigate the …

A cross-talk between sestrins, chronic inflammation and cellular senescence governs the development of age-associated sarcopenia and obesity

G Livshits, A Kalinkovich - Ageing Research Reviews, 2023 - Elsevier
The rapid increase in both the lifespan and proportion of older adults is accompanied by the
unprecedented rise in age-associated chronic diseases, including sarcopenia and obesity …