Background The inflammatory response is critical to fight insults, such as pathogen invasion
or tissue damage, but if not resolved often becomes detrimental to the host. A growing body …

Alcohol consumption and stress increase brain levels of known innate immune signaling
molecules. Microglia, the innate immune cells of the brain, and neurons respond to alcohol …

Toll-like receptors play an important role in the innate immune response, although emerging
evidence indicates their role in brain injury and neurodegeneration. Alcohol abuse induces …

Alcohol use disorder (AUD) is a highly prevalent, comorbid, and disabling disorder. The
underlying mechanism of ethanol neurotoxicity and the involvement of oxidative stress is still …

Alcohol use disorder (AUD) is a widespread disease with limited treatment options.
Targeting the neuroimmune system is a new avenue for develo** or repurposing effective …

Studies over the last decade demonstrate that adolescence is a brain maturation period from
childhood to adulthood. Plastic and dynamic processes drive adolescent brain development …

Toll-like receptors (TLRs) and NOD-like receptors (NLRs) are innate immunity sensors that
provide an early/effective response to pathogenic or injury conditions. We have reported that …

J. Neurochem.(2010) 114, 13–27. Abstract The responses of the brain to infection, ischemia
and trauma share remarkable similarities. These and other conditions of the CNS coordinate …

Microglial cells are the primary immune effector cells in the brain and play a pivotal role in
the neuroinflammatory processes associated with a variety of neurological and pathological …

Adolescent brain development seems to be important for the maturation of brain structures
and behaviour. Intermittent binge ethanol drinking is common among adolescents, and this …