C–H activation has surfaced as an increasingly powerful tool for molecular sciences, with
notable applications to material sciences, crop protection, drug discovery, and …

Conspectus To improve the efficacy of molecular syntheses, researchers wish to capitalize
upon the selective modification of otherwise inert C–H bonds. The past two decades have …

Late-stage functionalization of C–H bonds (C–H LSF) can provide a straightforward
approach to the efficient synthesis of functionalized complex molecules. However, C–H LSF …

Conspectus The functionalization of unactivated carbon–hydrogen bonds is a transformative
strategy for the rapid construction of molecular complexity given the ubiquitous presence of …

Direct catalytic transformation of C–H bonds to new functionalities has provided a powerful
strategy to synthesize complex molecular scaffolds in a straightforward way. Unstinting …

The development of new methods for the direct functionalization of unactivated C–H bonds
is ushering in a paradigm shift in the field of retrosynthetic analysis. In particular, the catalytic …

Computational studies on carboxylate-assisted C–H activation and functionalization at
group 8–10 transition metal centers are reviewed. This Review is organized by metal and …

Palladium-catalyzed aerobic oxidation reactions have been the focus of industrial
application and extensive research efforts for nearly 60 years. A significant transition …

Direct (hetero) arylation polymerization (DHAP) has recently been established as an
environmentally benign method for the preparation of conjugated polymers. This synthetic …

Transition-metal-catalyzed reactions have been studied since the very beginning of the past
century and represent a great success in organic chemistry, along with the birth and growth …