The causes and consequences of HIV evolution
Understanding the evolution of the human immunodeficiency virus (HIV) is crucial for
reconstructing its origin, deciphering its interaction with the immune system and develo** …
reconstructing its origin, deciphering its interaction with the immune system and develo** …
T cell dynamics in HIV-1 infection
DC Douek, LJ Picker, RA Koup - Annual review of immunology, 2003 - annualreviews.org
▪ Abstract In the absence of antiretroviral treatment, HIV-1 establishes a chronic, progressive
infection of the human immune system that invariably, over the course of years, leads to its …
infection of the human immune system that invariably, over the course of years, leads to its …
Viral immune evasion due to persistence of activated T cells without effector function
AJ Zajac, JN Blattman, K Murali-Krishna… - The Journal of …, 1998 - rupress.org
We examined the regulation of virus-specific CD8 T cell responses during chronic
lymphocytic choriomeningitis virus (LCMV) infection of mice. Our study shows that within the …
lymphocytic choriomeningitis virus (LCMV) infection of mice. Our study shows that within the …
Control of Viremia in Simian Immunodeficiency Virus Infection by CD8+ Lymphocytes
JE Schmitz, MJ Kuroda, S Santra, VG Sasseville… - Science, 1999 - science.org
Clinical evidence suggests that cellular immunity is involved in controlling human
immunodeficiency virus–1 (HIV-1) replication. An animal model of acquired immune …
immunodeficiency virus–1 (HIV-1) replication. An animal model of acquired immune …
Viral persistence alters CD8 T-cell immunodominance and tissue distribution and results in distinct stages of functional impairment
Chronic viral infections often result in ineffective CD8 T-cell responses due to functional
exhaustion or physical deletion of virus-specific T cells. However, how persisting virus …
exhaustion or physical deletion of virus-specific T cells. However, how persisting virus …
HIV nonprogressors preferentially maintain highly functional HIV-specific CD8+ T cells
Establishing a CD8+ T cell–mediated immune correlate of protection in HIV disease is
crucial to the development of vaccines designed to generate cell-mediated immunity …
crucial to the development of vaccines designed to generate cell-mediated immunity …
Dramatic Rise in Plasma Viremia after CD8+ T Cell Depletion in Simian Immunodeficiency Virus–infected Macaques
X **, DE Bauer, SE Tuttleton, S Lewin… - The Journal of …, 1999 - rupress.org
To determine the role of CD8+ T cells in controlling simian immunodeficiency virus (SIV)
replication in vivo, we examined the effect of depleting this cell population using an anti-CD8 …
replication in vivo, we examined the effect of depleting this cell population using an anti-CD8 …
Expression of CD57 defines replicative senescence and antigen-induced apoptotic death of CD8+ T cells
Virus-specific CD8+ T-cell responses play a pivotal role in limiting viral replication.
Alterations in these responses, such as decreased cytolytic function, inappropriate …
Alterations in these responses, such as decreased cytolytic function, inappropriate …
Analysis of successful immune responses in persons infected with hepatitis C virus
F Lechner, DKH Wong, PR Dunbar… - The Journal of …, 2000 - rupress.org
Although hepatitis C virus (HCV) infection is very common, identification of patients during
acute infection is rare. Consequently, little is known about the immune response during this …
acute infection is rare. Consequently, little is known about the immune response during this …
CD8+ T-cell responses to different HIV proteins have discordant associations with viral load
P Kiepiela, K Ngumbela, C Thobakgale, D Ramduth… - Nature medicine, 2007 - nature.com
Selection of T-cell vaccine antigens for chronic persistent viral infections has been largely
empirical. To define the relationship, at the population level, between the specificity of the …
empirical. To define the relationship, at the population level, between the specificity of the …