Inflammation and skeletal muscle wasting during cachexia

JM Webster, LJAP Kempen, RS Hardy… - Frontiers in …, 2020 - frontiersin.org
Cachexia is the involuntary loss of muscle and adipose tissue that strongly affects mortality
and treatment efficacy in patients with cancer or chronic inflammatory disease. Currently, no …

Long‐COVID syndrome‐associated brain fog and chemofog: Luteolin to the rescue

TC Theoharides, C Cholevas, K Polyzoidis… - Biofactors, 2021 - Wiley Online Library
COVID‐19 leads to severe respiratory problems, but also to long‐COVID syndrome
associated primarily with cognitive dysfunction and fatigue. Long‐COVID syndrome …

Developmental trajectories of early life stress and trauma: a narrative review on neurobiological aspects beyond stress system dysregulation

A Agorastos, P Pervanidou, GP Chrousos… - Frontiers in …, 2019 - frontiersin.org
Early life stressors display a high universal prevalence and constitute a major public health
problem. Prolonged psychoneurobiological alterations as sequelae of early life stress (ELS) …

Role of interleukin-6 in depressive disorder

EYC Ting, AC Yang, SJ Tsai - International journal of molecular sciences, 2020 - mdpi.com
Major depressive disorder (MDD), which is a leading psychiatric illness across the world,
severely affects quality of life and causes an increased incidence of suicide. Evidence from …

Fatigue in inflammatory rheumatic diseases: current knowledge and areas for future research

K Davies, E Dures, WF Ng - Nature Reviews Rheumatology, 2021 - nature.com
Fatigue is a complex phenomenon and an important health concern for many people with
chronic inflammatory rheumatic diseases, such as rheumatoid arthritis, psoriatic arthritis …

Obesity, oxidative stress, adipose tissue dysfunction, and the associated health risks: causes and therapeutic strategies

P Manna, SK Jain - Metabolic syndrome and related disorders, 2015 - liebertpub.com
Obesity is gaining acceptance as a serious primary health burden that impairs the quality of
life because of its associated complications, including diabetes, cardiovascular diseases …

Roles of β-endorphin in stress, behavior, neuroinflammation, and brain energy metabolism

A Pilozzi, C Carro, X Huang - International journal of molecular sciences, 2020 - mdpi.com
β-Endorphins are peptides that exert a wide variety of effects throughout the body. Produced
through the cleavage pro-opiomelanocortin (POMC), β-endorphins are the primarily agonist …

[HTML][HTML] Stress: endocrine physiology and pathophysiology

C Tsigos, I Kyrou, E Kassi, GP Chrousos - Endotext [Internet], 2020 - ncbi.nlm.nih.gov
Stress constitutes a state of threatened homeostasis triggered by intrinsic or extrinsic
adverse forces (stressors) and is counteracted by an intricate repertoire of physiologic and …

Role of SARS-CoV-2 spike-protein-induced activation of microglia and mast cells in the pathogenesis of neuro-COVID

TC Theoharides, D Kempuraj - Cells, 2023 - mdpi.com
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) causes coronavirus
disease 2019 (COVID-19). About 45% of COVID-19 patients experience several symptoms a …

Susceptibility for some infectious diseases in patients with diabetes: the key role of glycemia

J Chávez-Reyes, CE Escárcega-González… - Frontiers in public …, 2021 - frontiersin.org
Uncontrolled diabetes results in several metabolic alterations including hyperglycemia.
Indeed, several preclinical and clinical studies have suggested that this condition may …