Inherited retinal diseases: linking genes, disease-causing variants, and relevant therapeutic modalities

N Schneider, Y Sundaresan, P Gopalakrishnan… - Progress in retinal and …, 2022 - Elsevier
Inherited retinal diseases (IRDs) are a clinically complex and heterogenous group of visual
impairment phenotypes caused by pathogenic variants in at least 277 nuclear and …

RNA structures in alternative splicing and back‐splicing

B Xu, Y Meng, Y ** - Wiley Interdisciplinary Reviews: RNA, 2021 - Wiley Online Library
Alternative splicing greatly expands the transcriptomic and proteomic diversities related to
physiological and developmental processes in higher eukaryotes. Splicing of long …

A chromosome-scale genome assembly and karyotype of the ctenophore Hormiphora californensis

DT Schultz, WR Francis, JD McBroome… - G3, 2021 - academic.oup.com
Here, we present a karyotype, a chromosome-scale genome assembly, and a genome
annotation from the ctenophore Hormiphora californensis (Ctenophora: Cydippida …

Regulatory mechanisms ensuring coordinated expression of functionally related genes

OQH Zinani, K Keseroğlu, EM Özbudak - Trends in Genetics, 2022 - cell.com
Coordinated spatiotemporal expression of large sets of genes is required for the
development and homeostasis of organisms. To achieve this goal, organisms use myriad …

Assembled chromosomes of the blood fluke Schistosoma mansoni provide insight into the evolution of its ZW sex-determination system

SK Buddenborg, A Tracey, DJ Berger, Z Lu, SR Doyle… - BioRxiv, 2021 - biorxiv.org
Background Schistosoma mansoni is a flatworm that causes a neglected tropical disease
affecting millions worldwide. Most flatworms are hermaphrodites but schistosomes have …

Complete representation of a tapeworm genome reveals chromosomes capped by centromeres, necessitating a dual role in segregation and protection

PD Olson, A Tracey, A Baillie, K James, SR Doyle… - BMC biology, 2020 - Springer
Background Chromosome-level assemblies are indispensable for accurate gene prediction,
synteny assessment, and understanding higher-order genome architecture. Reference and …

Mutational profile of the regenerative process and de novo genome assembly of the planarian Schmidtea polychroa

Á Póti, D Szüts, J Vermezovic - Nucleic Acids Research, 2024 - academic.oup.com
Planarians are organisms with a unique capacity to regenerate any part of their body. New
tissues are generated in a process that requires many swift cell divisions. How costly is this …

Monodopsis and Vischeria Genomes Shed New Light on the Biology of Eustigmatophyte Algae

HP Yang, M Wenzel, DA Hauser… - Genome biology and …, 2021 - academic.oup.com
Members of eustigmatophyte algae, especially Nannochloropsis and Microchloropsis, have
been tapped for biofuel production owing to their exceptionally high lipid content. Although …

Hypothesis: Trans‐splicing Generates Evolutionary Novelty in the Photosynthetic Amoeba Paulinella

A Gabr, TG Stephens, D Bhattacharya - Journal of Phycology, 2022 - Wiley Online Library
Plastid primary endosymbiosis has occurred twice, once in the Archaeplastida ancestor and
once in the Paulinella (Rhizaria) lineage. Both events precipitated massive evolutionary …

Profiling Transcriptional Regulation and Functional Roles of Schistosoma mansoni c-Jun N-Terminal Kinase

SG Gava, NC Tavares, FH Falcone, G Oliveira… - Frontiers in …, 2019 - frontiersin.org
Mitogen-activated protein kinases (MAPKs) play a regulatory role and influence various
biological activities, such as cell proliferation, differentiation, and survival. Our group has …