Inherited retinal diseases: linking genes, disease-causing variants, and relevant therapeutic modalities
N Schneider, Y Sundaresan, P Gopalakrishnan… - Progress in retinal and …, 2022 - Elsevier
Inherited retinal diseases (IRDs) are a clinically complex and heterogenous group of visual
impairment phenotypes caused by pathogenic variants in at least 277 nuclear and …
impairment phenotypes caused by pathogenic variants in at least 277 nuclear and …
RNA structures in alternative splicing and back‐splicing
B Xu, Y Meng, Y ** - Wiley Interdisciplinary Reviews: RNA, 2021 - Wiley Online Library
Alternative splicing greatly expands the transcriptomic and proteomic diversities related to
physiological and developmental processes in higher eukaryotes. Splicing of long …
physiological and developmental processes in higher eukaryotes. Splicing of long …
A chromosome-scale genome assembly and karyotype of the ctenophore Hormiphora californensis
Here, we present a karyotype, a chromosome-scale genome assembly, and a genome
annotation from the ctenophore Hormiphora californensis (Ctenophora: Cydippida …
annotation from the ctenophore Hormiphora californensis (Ctenophora: Cydippida …
Regulatory mechanisms ensuring coordinated expression of functionally related genes
Coordinated spatiotemporal expression of large sets of genes is required for the
development and homeostasis of organisms. To achieve this goal, organisms use myriad …
development and homeostasis of organisms. To achieve this goal, organisms use myriad …
Assembled chromosomes of the blood fluke Schistosoma mansoni provide insight into the evolution of its ZW sex-determination system
Background Schistosoma mansoni is a flatworm that causes a neglected tropical disease
affecting millions worldwide. Most flatworms are hermaphrodites but schistosomes have …
affecting millions worldwide. Most flatworms are hermaphrodites but schistosomes have …
Complete representation of a tapeworm genome reveals chromosomes capped by centromeres, necessitating a dual role in segregation and protection
Background Chromosome-level assemblies are indispensable for accurate gene prediction,
synteny assessment, and understanding higher-order genome architecture. Reference and …
synteny assessment, and understanding higher-order genome architecture. Reference and …
Mutational profile of the regenerative process and de novo genome assembly of the planarian Schmidtea polychroa
Á Póti, D Szüts, J Vermezovic - Nucleic Acids Research, 2024 - academic.oup.com
Planarians are organisms with a unique capacity to regenerate any part of their body. New
tissues are generated in a process that requires many swift cell divisions. How costly is this …
tissues are generated in a process that requires many swift cell divisions. How costly is this …
Monodopsis and Vischeria Genomes Shed New Light on the Biology of Eustigmatophyte Algae
HP Yang, M Wenzel, DA Hauser… - Genome biology and …, 2021 - academic.oup.com
Members of eustigmatophyte algae, especially Nannochloropsis and Microchloropsis, have
been tapped for biofuel production owing to their exceptionally high lipid content. Although …
been tapped for biofuel production owing to their exceptionally high lipid content. Although …
Hypothesis: Trans‐splicing Generates Evolutionary Novelty in the Photosynthetic Amoeba Paulinella
Plastid primary endosymbiosis has occurred twice, once in the Archaeplastida ancestor and
once in the Paulinella (Rhizaria) lineage. Both events precipitated massive evolutionary …
once in the Paulinella (Rhizaria) lineage. Both events precipitated massive evolutionary …
Profiling Transcriptional Regulation and Functional Roles of Schistosoma mansoni c-Jun N-Terminal Kinase
Mitogen-activated protein kinases (MAPKs) play a regulatory role and influence various
biological activities, such as cell proliferation, differentiation, and survival. Our group has …
biological activities, such as cell proliferation, differentiation, and survival. Our group has …