Inflammation in obesity, diabetes, and related disorders
Obesity leads to chronic, systemic inflammation and can lead to insulin resistance (IR), β-cell
dysfunction, and ultimately type 2 diabetes (T2D). This chronic inflammatory state …
dysfunction, and ultimately type 2 diabetes (T2D). This chronic inflammatory state …
[HTML][HTML] The role of inflammation in diabetes: current concepts and future perspectives
S Tsalamandris, AS Antonopoulos… - European cardiology …, 2019 - ncbi.nlm.nih.gov
Diabetes is a complex metabolic disorder affecting the glucose status of the human body.
Chronic hyperglycaemia related to diabetes is associated with end organ failure. The clinical …
Chronic hyperglycaemia related to diabetes is associated with end organ failure. The clinical …
[HTML][HTML] Contribution of adipose tissue inflammation to the development of type 2 diabetes mellitus
MS Burhans, DK Hagman, JN Kuzma… - Comprehensive …, 2018 - ncbi.nlm.nih.gov
The objective of this comprehensive review is to summarize and discuss the available
evidence of how adipose tissue inflammation affects insulin sensitivity and glucose …
evidence of how adipose tissue inflammation affects insulin sensitivity and glucose …
Targeting inflammation in the treatment of type 2 diabetes: time to start
MY Donath - Nature reviews Drug discovery, 2014 - nature.com
The role of inflammation in the pathogenesis of type 2 diabetes and associated
complications is now well established. Several conditions that are driven by inflammatory …
complications is now well established. Several conditions that are driven by inflammatory …
[HTML][HTML] Diabetes mellitus: Classification, mediators, and complications; A gate to identify potential targets for the development of new effective treatments
Nowadays, diabetes mellitus has emerged as a significant global public health concern with
a remarkable increase in its prevalence. This review article focuses on the definition of …
a remarkable increase in its prevalence. This review article focuses on the definition of …
Molecular and pathophysiological relationship between obesity and chronic inflammation in the manifestation of metabolic dysfunctions and their inflammation …
Obesity reaches up to epidemic proportions globally and increases the risk for a wide
spectrum of co-morbidities, including type-2 diabetes mellitus (T2DM), hypertension …
spectrum of co-morbidities, including type-2 diabetes mellitus (T2DM), hypertension …
Anti-inflammatory agents in the treatment of diabetes and its vascular complications
RM Pollack, MY Donath, D LeRoith… - Diabetes care, 2016 - Am Diabetes Assoc
The association between hyperglycemia and inflammation and vascular complications in
diabetes is now well established. Antidiabetes drugs may alleviate inflammation by reducing …
diabetes is now well established. Antidiabetes drugs may alleviate inflammation by reducing …
Inflammation in obesity and diabetes: islet dysfunction and therapeutic opportunity
MY Donath, É Dalmas, NS Sauter, M Böni-Schnetzler - Cell metabolism, 2013 - cell.com
The role of the immune system is to restore functionality in response to stress. Increasing
evidence shows that this function is not limited to insults by infection or injury and plays a …
evidence shows that this function is not limited to insults by infection or injury and plays a …
Anti-inflammatory agents to treat or prevent type 2 diabetes, metabolic syndrome and cardiovascular disease
Introduction: There is a growing body of evidence to suggest that chronic silent inflammation
is a key feature in abdominal obesity, metabolic syndrome, type 2 diabetes (T2DM) and …
is a key feature in abdominal obesity, metabolic syndrome, type 2 diabetes (T2DM) and …
Adiposity and insulin resistance in humans: the role of the different tissue and cellular lipid depots
Human adiposity has long been associated with insulin resistance and increased
cardiovascular risk, and abdominal adiposity is considered particularly adverse. Intra …
cardiovascular risk, and abdominal adiposity is considered particularly adverse. Intra …