Fibrosis results from defective wound healing processes often seen after chronic injury
and/or inflammation in a range of organs. Progressive fibrotic events may lead to permanent …

The Yes‐associated protein and its transcriptional coactivator with PDZ‐binding motif
(YAP/TAZ) are two homologous transcriptional coactivators that lie at the center of a key …

The mechanistic target of rapamycin (mTOR) is a serine/threonine protein kinase that
regulates multiple processes, including gene transcription, protein synthesis, ribosome …

Myocardial fibrosis post myocardial infarction (MI) is characterized by abnormal extracellular
matrix (ECM) deposition and cardiac dysfunction could finally develop into serious heart …

The Hippo pathway was initially discovered in Drosophila melanogaster and mammals as a
key regulator of tissue growth both in physiological and pathological states. Numerous …

Yes-associated protein (YAP) and transcriptional coactivator with PDZ-binding motif (TAZ)
serve as transcriptional co-activators that dynamically shuttle between the cytoplasm and …

Idiopathic pulmonary fibrosis (IPF) consists of fibrotic alveolar remodeling and progressive
loss of pulmonary function. Genetic and experimental evidence indicates that chronic …

The transcriptional co-activator Yes-associated protein (YAP) functions as a downstream
effector of the Hippo signaling pathway and plays a crucial role in cardiomyocyte survival. In …

The Hippo-yes-associated protein (YAP) signaling pathway plays a crucial role in cell
proliferation, differentiation, and death. It is known to have impact on the progression and …

Background The gap junction protein connexin 43 (Cx43) has been implicated in the
development of cardiac fibrosis. Our previous findings revealed that Cx43 …