Highlights•CCS distributions and shifts contain valuable information about
analytes.•Compound-dependent effects of gas, field and temperature explain calibration …

Electrospray ionization (ESI) is an essential technique for transferring proteins from solution
into the gas phase for mass spectrometry and ion mobility spectrometry. The mechanisms …

The mechanisms behind the Amyloid-β (Aβ) peptide neurotoxicity in Alzheimer's disease are
intensely studied and under debate. One suggested mechanism is that the peptides …

Native ion mobility-mass spectrometry (IM-MS) is a rapidly growing field for studying the
composition and structure of biomolecules and biomolecular complexes using gas-phase …

Recent advances in instrumentation and development of computational strategies for ion
mobility mass spectrometry (IM‐MS) studies have contributed to an extensive growth in the …

Experiments and molecular dynamics (MD) simulations in the literature indicate that
gaseous proteins generated by electrospray ionization (ESI) can retain native-like structures …

The ion evaporation model (IEM) and the charged residue model (CRM) represent
cornerstones of any discussion related to the mechanism of electrospray ionization (ESI) …

In this review, we detail the most common experimental approaches to assess and
characterize protein intrinsic structural disorder, with the notable exception of NMR and EPR …

Entire functional proteins as well as large regions of proteins lack structural elements which
are resolvable via crystallography or NMR. These intrinsically disordered proteins (IDPs) or …

Lactoferrin (Lf), a multifunctional protein found abundantly in secretions, including tears,
plays a crucial role in ocular health through its antimicrobial, immunoregulatory, anti …