Most of the anticancer chemotherapeutic drugs that are broadly and successfully used today
are DNA-damaging agents. Targeting of DNA has been proven to cause relatively potent …

▪ Abstract Is it by design or by default that water molecules are observed at the interfaces of
some protein-DNA complexes? Both experimental and theoretical studies on the …

Principles of Nucleic Acid Structure, Second Edition, provides the most complete and
concise summary of underlying principles and approaches to studying nucleic acid structure …

We investigate the conservation of amino acid residue sequences in 21 DNA-binding
protein families and study the effects that mutations have on DNA-sequence recognition …

A large number of inorganic and organic compounds is able to bind to DNA and form
complexes. Among them, drugs are very important, especially chemotherapeutics. This …

DNA is an important target for the treatment of multiple pathologies, most notably cancer. In
particular, DNA intercalators have often been used as anticancer drugs. However, despite …

Small molecules that bind genomic DNA have proven that they can be effective anticancer,
antibiotic and antiviral therapeutic agents that affect the well-being of millions of people …

Characterizing the genome of mature virions is pivotal to understanding the highly dynamic
processes of virus assembly and infection. Owing to the different cellular fates of DNA and …

Background The B-DNA major and minor groove dimensions are crucial for DNA-protein
interactions. It has long been thought that the groove dimensions depend on the DNA …

DNA–protein interaction is one of the most crucial interactions in the biological system,
which decides the fate of many processes such as transcription, regulation and splicing of …