Alkaline phosphatase in clinical practice in childhood: Focus on rickets

G Cannalire, S Pilloni, S Esposito, G Biasucci… - Frontiers in …, 2023 - frontiersin.org
Serum alkaline phosphatase (ALP) and its isoenzymes reflect bone metabolism: ALP
increases the ratio of inorganic phosphate to pyrophosphate systemically and facilitates …

[HTML][HTML] Genetics and epigenetics of bone remodeling and metabolic bone diseases

L Oton-Gonzalez, C Mazziotta, MR Iaquinta… - International Journal of …, 2022 - mdpi.com
Bone metabolism consists of a balance between bone formation and bone resorption, which
is mediated by osteoblast and osteoclast activity, respectively. In order to ensure bone …

[HTML][HTML] Rickets in children: an update

C Gentile, F Chiarelli - Biomedicines, 2021 - mdpi.com
Rickets refers to a deficient mineralization of the growth plate cartilage, predominantly
affecting longer bones. Despite the fact that preventive measures are available, it is still a …

Rickets Types and Treatment with Vitamin D and Analogues

G Biasucci, V Donini, G Cannalire - Nutrients, 2024 - mdpi.com
The definition of “Vitamin D” encompasses a group of fat-soluble steroid compounds of
different origins with similar chemical structures and the same biological effects. Vitamin D …

Rickets guidance: part II—management

D Haffner, M Leifheit-Nestler, A Grund, D Schnabel - Pediatric Nephrology, 2022 - Springer
Here, we discuss the management of different forms of rickets, including new therapeutic
approaches based on recent guidelines. Management includes close monitoring of growth …

An Update on Vitamin D Deficiency in the twenty-first century: nature and nurture

AJ Stoffers, DR Weber, MA Levine - Current Opinion in …, 2022 - journals.lww.com
Vitamin D levels in individuals are influenced by environmental factors, as well as genetic
factors. A thorough understanding of these factors is critical for the evaluation and treatment …

Transdermal drug delivery via microneedles for musculoskeletal systems

H Zheng, X **e, H Ling, X You, S Liang, R Lin… - Journal of Materials …, 2023 - pubs.rsc.org
As the population is ageing and lifestyle is changing, the prevalence of musculoskeletal
(MSK) disorders is gradually increasing with each passing year, posing a serious threat to …

Cooling and lighting effects of new plastic optical fiber lighting system based on high-transmittance heat-insulating film

N Liu, S **n, S Liu, X Zhang, W Xu, F Wang - Energy and Buildings, 2024 - Elsevier
Using plastic optical fibers (POFs) to channel sunlight for indoor lighting is an emerging
approach for solar energy utilization. In this study, a long focal length mobile dual-axis …

Broad application prospects of bone turnover markers in pediatrics

Y Zhang, X Huang, C Li, J Zhang, X Yu… - Journal of clinical …, 2022 - Wiley Online Library
Abstract Background Bone turnover markers (BTMs) have been studied for application in
clinical medicine. However, BTMs in children are challenging, and few studies explore these …

Compounding vulnerabilities: Syndemics and the social determinants of disease in the past

MA Perry, RL Gowland - International Journal of Paleopathology, 2022 - Elsevier
Objective This article explores the theory and utility of a syndemic approach for the study of
disease in the past. Syndemic principles are examined alongside other theoretical …