The immunopathogenesis of narcolepsy type 1
Abstract Narcolepsy type 1 (NT1) is a chronic sleep disorder resulting from the loss of a
small population of hypothalamic neurons that produce wake-promoting hypocretin (HCRT; …
small population of hypothalamic neurons that produce wake-promoting hypocretin (HCRT; …
[HTML][HTML] Genetics of sleep and sleep disorders
Sleep remains one of the least understood phenomena in biology—even its role in synaptic
plasticity remains debatable. Since sleep was recognized to be regulated genetically …
plasticity remains debatable. Since sleep was recognized to be regulated genetically …
Autoimmunity to hypocretin and molecular mimicry to flu in type 1 narcolepsy
Type 1 narcolepsy (T1N) is caused by hypocretin/orexin (HCRT) neuronal loss. Association
with the HLA DQB1* 06: 02/DQA1* 01: 02 (98% vs. 25%) heterodimer (DQ0602), T cell …
with the HLA DQB1* 06: 02/DQA1* 01: 02 (98% vs. 25%) heterodimer (DQ0602), T cell …
Increased incidence and clinical picture of childhood narcolepsy following the 2009 H1N1 pandemic vaccination campaign in Finland
M Partinen, O Saarenpää-Heikkilä, I Ilveskoski… - PloS one, 2012 - journals.plos.org
Background Narcolepsy is a rare neurological sleep disorder especially in children who are
younger than 10 years. In the beginning of 2010, an exceptionally large number of Finnish …
younger than 10 years. In the beginning of 2010, an exceptionally large number of Finnish …
ImmunoChip study implicates antigen presentation to T cells in narcolepsy
Recent advances in the identification of susceptibility genes and environmental exposures
provide broad support for a post-infectious autoimmune basis for narcolepsy/hypocretin …
provide broad support for a post-infectious autoimmune basis for narcolepsy/hypocretin …
Genome wide analysis of narcolepsy in China implicates novel immune loci and reveals changes in association prior to versus after the 2009 H1N1 influenza …
Previous studies in narcolepsy, an autoimmune disorder affecting hypocretin (orexin)
neurons and recently associated with H1N1 influenza, have demonstrated significant …
neurons and recently associated with H1N1 influenza, have demonstrated significant …
Characterization of T cell receptors reactive to HCRTNH2, pHA273-287, and NP17-31 in control and narcolepsy patients
G Luo, J Zhang, L Lin… - Proceedings of the …, 2022 - National Acad Sciences
Narcolepsy type 1 (NT1), a disorder caused by hypocretin/orexin (HCRT) cell loss, is
associated with human leukocyte antigen (HLA)-DQ0602 (98%) and T cell receptor (TCR) …
associated with human leukocyte antigen (HLA)-DQ0602 (98%) and T cell receptor (TCR) …
Narcolepsy: autoimmunity, effector T cell activation due to infection, or T cell independent, major histocompatibility complex class II induced neuronal loss?
Human narcolepsy with cataplexy is a neurological disorder, which develops due to a
deficiency in hypocretin producing neurons in the hypothalamus. There is a strong …
deficiency in hypocretin producing neurons in the hypothalamus. There is a strong …
Investigation of an association between onset of narcolepsy and vaccination with pandemic influenza vaccine, Ireland April 2009-December 2010
D O'flanagan, AS Barret, M Foley, S Cotter… - …, 2014 - eurosurveillance.org
Investigation of an association between onset of narcolepsy and vaccination with pandemic
influenza vaccine, Ireland April 2009- Page 1 5 www.eurosurveillance.org Research articles …
influenza vaccine, Ireland April 2009- Page 1 5 www.eurosurveillance.org Research articles …
Narcolepsy type I-associated DNA methylation and gene expression changes in the human leukocyte antigen region
K Yoshida-Tanaka, M Shimada, Y Honda… - Scientific Reports, 2023 - nature.com
Abstract Narcolepsy type 1 (NT1) is caused by a loss of hypothalamic orexin-producing
cells, and autoreactive CD4+ and CD8+ T cells have been suggested to play a role in the …
cells, and autoreactive CD4+ and CD8+ T cells have been suggested to play a role in the …