Effect of ω-3 polyunsaturated fatty acids-derived bioactive lipids on metabolic disorders

J Duan, Y Song, X Zhang, C Wang - Frontiers in physiology, 2021 - frontiersin.org
Arachidonic acid (ARA) is an important ω-6 polyunsaturated fatty acid (PUFA), and
docosahexaenoic acid (DHA), eicosapentaenoic acid (EPA) and n-3 docosapentaenoic acid …

Plant sterol ester of α-linolenic acid improved non-alcoholic fatty liver disease by attenuating endoplasmic reticulum stress-triggered apoptosis via activation of the …

H Han, T Xue, J Li, Y Guo, X Li, L Wang, L Pei… - The Journal of nutritional …, 2022 - Elsevier
Apoptosis is a feature of progressions steatosis to nonalcoholic steatohepatitis (NASH) and
can be explained by endoplasmic reticulum stress (ERS). The present study aimed to …

Plant sterol ester of α-linolenic acid ameliorates high-fat diet-induced nonalcoholic fatty liver disease in mice: association with regulating mitochondrial dysfunction …

H Han, X Li, Y Guo, M Zheng, T Xue, L Wang - Food & function, 2021 - pubs.rsc.org
The present study was designed to explore the beneficial mitochondrial effects and anti-
oxidative activities of plant sterol ester of α-linolenic acid (PS-ALA) through AMP-activated …

Gynostemma pentaphyllum Extract Alleviates NASH in Mice: Exploration of Inflammation and Gut Microbiota

FY Jiang, SR Yue, YY Tan, N Tang, YS Xu, BJ Zhang… - Nutrients, 2024 - mdpi.com
NASH (non-alcoholic steatohepatitis) is a severe liver disease characterized by hepatic
chronic inflammation that can be associated with the gut microbiota. In this study, we …

Vitamin D3 enhances the effects of omega‐3 oils against metabolic dysfunction‐associated fatty liver disease in rat

B Refaat, AH Abdelghany, J Ahmad, OM Abdalla… - Biofactors, 2022 - Wiley Online Library
This study investigated the effects of omega‐3 oils (OM) and/or vitamin D3 (VD) against
metabolic dysfunction‐associated fatty liver disease (MAFLD). Forty rats were divided into …

DHA/EPA supplementation decreases anxiety-like behaviour, but it does not ameliorate metabolic profile in obese male rats

J Neto, J Jantsch, S de Oliveira, MF Braga… - British Journal of …, 2022 - cambridge.org
Obesity is a major public health problem that predisposes to several diseases and higher
mortality in patients with COVID-19. Obesity also generates neuroinflammation, which …

Through regulation of the SIRT1 pathway plant sterol ester of α-linolenic acid inhibits pyroptosis thereby attenuating the development of NASH in mice

H Han, J Li, L Tian, L Pei, M Zheng - The Journal of Nutritional Biochemistry, 2023 - Elsevier
Increasing evidence demonstrated that pyroptosis and subsequent inflammation played an
important role in the pathological process of non-alcoholic steatohepatitis (NASH). Plant …