Circular RNAs' cap-independent translation protein and its roles in carcinomas
L He, C Man, S **ang, L Yao, X Wang, Y Fan - Molecular cancer, 2021 - Springer
Circular RNAs a kind of covalently closed RNA and widely expressed in eukaryotes.
CircRNAs are involved in a variety of physiological and pathological processes, but their …
CircRNAs are involved in a variety of physiological and pathological processes, but their …
Intron retention and its impact on gene expression and protein diversity: A review and a practical guide
DF Grabski, L Broseus, B Kumari… - Wiley …, 2021 - Wiley Online Library
Intron retention (IR) occurs when a complete and unspliced intron remains in mature mRNA.
An increasing body of literature has demonstrated a major role for IR in numerous biological …
An increasing body of literature has demonstrated a major role for IR in numerous biological …
Dynamic methylome of internal mRNA N7-methylguanosine and its regulatory role in translation
L Malbec, T Zhang, YS Chen, Y Zhang, BF Sun, BY Shi… - Cell research, 2019 - nature.com
Over 150 types of RNA modifications are identified in RNA molecules. Transcriptome
profiling is one of the key steps in decoding the epitranscriptomic panorama of these …
profiling is one of the key steps in decoding the epitranscriptomic panorama of these …
Targeting EIF4A triggers an interferon response to synergize with chemotherapy and suppress triple-negative breast cancer
Protein synthesis is frequently dysregulated in cancer and selective inhibition of mRNA
translation represents an attractive cancer therapy. Here, we show that therapeutically …
translation represents an attractive cancer therapy. Here, we show that therapeutically …
[HTML][HTML] Pharmacological inhibition of arachidonate 12-lipoxygenase ameliorates myocardial ischemia-reperfusion injury in multiple species
XJ Zhang, X Liu, M Hu, GJ Zhao, D Sun, X Cheng… - Cell metabolism, 2021 - cell.com
Myocardial ischemia-reperfusion (MIR) injury is a major cause of adverse outcomes of
revascularization after myocardial infarction. To identify the fundamental regulator of …
revascularization after myocardial infarction. To identify the fundamental regulator of …
Altered ribosomal function and protein synthesis caused by tau
The synthesis of new proteins is a fundamental aspect of cellular life and is required for
many neurological processes, including the formation, updating and extinction of long-term …
many neurological processes, including the formation, updating and extinction of long-term …
Systems approaches identify the consequences of monosomy in somatic human cells
Chromosome loss that results in monosomy is detrimental to viability, yet it is frequently
observed in cancers. How cancers survive with monosomy is unknown. Using p53-deficient …
observed in cancers. How cancers survive with monosomy is unknown. Using p53-deficient …
The effects of codon bias and optimality on mRNA and protein regulation
The central dogma of molecular biology entails that genetic information is transferred from
nucleic acid to proteins. Notwithstanding retro-transcribing genetic elements, DNA is …
nucleic acid to proteins. Notwithstanding retro-transcribing genetic elements, DNA is …
Interaction of the La-related protein Slf1 with colliding ribosomes maintains translation of oxidative-stress responsive mRNAs
In response to oxidative stress cells reprogram gene expression to enhance levels of
antioxidant enzymes and promote survival. In Saccharomyces cerevisiae the polysome …
antioxidant enzymes and promote survival. In Saccharomyces cerevisiae the polysome …
Selective footprinting of 40S and 80S ribosome subpopulations (Sel-TCP-seq) to study translation and its control
Multiple aspects of mRNA translation are subject to regulation. Here we present a ribosome
footprinting protocol to determine the location and composition of 40S and 80S ribosome …
footprinting protocol to determine the location and composition of 40S and 80S ribosome …