Chromosomal replication must be limited to once and only once per cell cycle. This is
accomplished by multiple regulatory pathways that govern initiator proteins and replication …

How to adapt to a changing environment is a fundamental, recurrent problem confronting
cells. One solution is for cells to organize their constituents into a limited number of spatially …

Loading of the replicative DNA helicase at origins of replication is of central importance in
DNA replication. As the first of the replication fork proteins assemble at chromosomal origins …

In addition to playing a central role as a permeability barrier for controlling the diffusion of
molecules and ions in and out of bacterial cells, phospholipid (PL) membranes regulate the …

We examine whether the E scherichia coli chromosome is folded into a self‐adherent
nucleoprotein complex, or alternately is a confined but otherwise unconstrained self …

To ensure proper timing of chromosome duplication during the cell cycle, bacteria must
carefully regulate the activity of initiator protein DnaA and its interactions with the unique …

DnaA, the initiator of Escherichia coli chromosomal replication, has in its adenosine
triphosphatase (ATPase) domain residues required for adenosine 5′-triphosphate (ATP) …

Escherichia coli DnaA is the initiator of chromosomal replication. Multiple ATP-DnaA
molecules assemble at the oriC replication origin in a highly regulated manner, and the …

DnaA is a conserved key regulator of replication initiation in bacteria, and is homologous to
ORC proteins in archaea and in eukaryotic cells. The ATPase binds to several high affinity …

A fundamental problem in biology is how cells obtain the reproducible, coherent phenotypes
needed for natural selection to act or, put differently, how cells manage to limit their …