Cancer cell migration and invasion are integral components of metastatic disease, which is
the major cause of death in cancer patients. Cancer cells can disseminate and migrate via …

The tripartite-motif (TRIM) family represents one of the largest classes of putative single
protein RING-finger E3 ubiquitin ligases. TRIM family is involved in a variety of cellular …

Background Cuproptosis is a new type of copper-induced cell death that is characterized by
the aggregation of lipoylated tricarboxylic acid (TCA) cycle proteins. However, its role in …

Autophagy is intricately linked with many intracellular signaling pathways, particularly
nutrient-sensing mechanisms and cell death signaling cascades. In cancer, the roles of …

Background Exosomes are emerging as important mediators of the cross-talk between
tumor cells and the microenvironment. The communication between tumor-derived …

The cell cycle is a series of events by which cellular components are accurately segregated
into daughter cells, principally controlled by the oscillating activities of cyclin-dependent …

Ubiquitination is a critical type of post-translational modifications, of which K63-linked
ubiquitination regulates interaction, translocation, and activation of proteins. In recent years …

Targeting CD96 that originates in immune cells has shown potential for cancer therapy.
However, the role of intrinsic CD96 in solid tumor cells remains unknown. Here, it is found …

Autophagy is a self-digestion process in cells that can maintain energy homeostasis under
normal circumstances. However, misfolded proteins, damaged mitochondria and other …

Exosomes derived from human umbilical cord mesenchymal stem cells (HUCMSCs)
expressing microRNAs (miRs) have been highlighted as important carriers for gene or drug …