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[HTML][HTML] Molecular biomarkers in cancer
VK Sarhadi, G Armengol - Biomolecules, 2022 - mdpi.com
Molecular cancer biomarkers are any measurable molecular indicator of risk of cancer,
occurrence of cancer, or patient outcome. They may include germline or somatic genetic …
occurrence of cancer, or patient outcome. They may include germline or somatic genetic …
Whole genome sequencing in clinical practice
FO Bagger, L Borgwardt, AS Jespersen… - BMC medical …, 2024 - Springer
Whole genome sequencing (WGS) is becoming the preferred method for molecular genetic
diagnosis of rare and unknown diseases and for identification of actionable cancer drivers …
diagnosis of rare and unknown diseases and for identification of actionable cancer drivers …
Histopathologic and proteogenomic heterogeneity reveals features of clear cell renal cell carcinoma aggressiveness
Y Li, TSM Lih, SM Dhanasekaran, R Mannan, L Chen… - Cancer cell, 2023 - cell.com
Clear cell renal cell carcinomas (ccRCCs) represent∼ 75% of RCC cases and account for
most RCC-associated deaths. Inter-and intratumoral heterogeneity (ITH) results in varying …
most RCC-associated deaths. Inter-and intratumoral heterogeneity (ITH) results in varying …
[HTML][HTML] Proteogenomic characterization of pancreatic ductal adenocarcinoma
Pancreatic ductal adenocarcinoma (PDAC) is a highly aggressive cancer with poor patient
survival. Toward understanding the underlying molecular alterations that drive PDAC …
survival. Toward understanding the underlying molecular alterations that drive PDAC …
Genetic/familial high-risk assessment: breast, ovarian, and pancreatic, version 2.2021, NCCN clinical practice guidelines in oncology
MB Daly, T Pal, MP Berry, SS Buys, P Dickson… - Journal of the National …, 2021 - jnccn.org
The NCCN Guidelines for Genetic/Familial High-Risk Assessment: Breast, Ovarian, and
Pancreatic focus primarily on assessment of pathogenic or likely pathogenic variants …
Pancreatic focus primarily on assessment of pathogenic or likely pathogenic variants …
A human breast cancer-derived xenograft and organoid platform for drug discovery and precision oncology
KP Guillen, M Fujita, AJ Butterfield, SD Scherer… - Nature cancer, 2022 - nature.com
Abstract Models that recapitulate the complexity of human tumors are urgently needed to
develop more effective cancer therapies. We report a bank of human patient-derived …
develop more effective cancer therapies. We report a bank of human patient-derived …
Scalable Nanopore sequencing of human genomes provides a comprehensive view of haplotype-resolved variation and methylation
M Kolmogorov, KJ Billingsley, M Mastoras… - Nature …, 2023 - nature.com
Long-read sequencing technologies substantially overcome the limitations of short-reads
but have not been considered as a feasible replacement for population-scale projects, being …
but have not been considered as a feasible replacement for population-scale projects, being …
[HTML][HTML] Mammalian SWI/SNF chromatin remodeling complexes promote tyrosine kinase inhibitor resistance in EGFR-mutant lung cancer
FJ de Miguel, C Gentile, WW Feng, SJ Silva, A Sankar… - Cancer Cell, 2023 - cell.com
Acquired resistance to tyrosine kinase inhibitors (TKI), such as osimertinib used to treat
EGFR-mutant lung adenocarcinomas, limits long-term efficacy and is frequently caused by …
EGFR-mutant lung adenocarcinomas, limits long-term efficacy and is frequently caused by …
Pan-cancer whole-genome analyses of metastatic solid tumours
Metastatic cancer is a major cause of death and is associated with poor treatment efficacy. A
better understanding of the characteristics of late-stage cancer is required to help adapt …
better understanding of the characteristics of late-stage cancer is required to help adapt …
Genomic and evolutionary classification of lung cancer in never smokers
T Zhang, P Joubert, N Ansari-Pour, W Zhao… - Nature …, 2021 - nature.com
Lung cancer in never smokers (LCINS) is a common cause of cancer mortality but its
genomic landscape is poorly characterized. Here high-coverage whole-genome sequencing …
genomic landscape is poorly characterized. Here high-coverage whole-genome sequencing …