Prohibitins: a critical role in mitochondrial functions and implication in diseases
A Signorile, G Sgaramella, F Bellomo, D De Rasmo - Cells, 2019 - mdpi.com
Prohibitin 1 (PHB1) and prohibitin 2 (PHB2) are proteins that are ubiquitously expressed,
and are present in the nucleus, cytosol, and mitochondria. Depending on the cellular …
and are present in the nucleus, cytosol, and mitochondria. Depending on the cellular …
Sha** the mitochondrial inner membrane in health and disease
L Colina‐Tenorio, P Horten, N Pfanner… - Journal of internal …, 2020 - Wiley Online Library
Mitochondria play central roles in cellular energetics, metabolism and signalling. Efficient
respiration, mitochondrial quality control, apoptosis and inheritance of mitochondrial DNA …
respiration, mitochondrial quality control, apoptosis and inheritance of mitochondrial DNA …
NAD+ repletion improves mitochondrial and stem cell function and enhances life span in mice
Adult stem cells (SCs) are essential for tissue maintenance and regeneration yet are
susceptible to senescence during aging. We demonstrate the importance of the amount of …
susceptible to senescence during aging. We demonstrate the importance of the amount of …
CARL lncRNA inhibits anoxia-induced mitochondrial fission and apoptosis in cardiomyocytes by impairing miR-539-dependent PHB2 downregulation
K Wang, BO Long, LY Zhou, F Liu, QY Zhou… - Nature …, 2014 - nature.com
Abnormal mitochondrial fission participates in the pathogenesis of many diseases. Long non-
coding RNAs (lncRNAs) are emerging as new players in gene regulation, but how lncRNAs …
coding RNAs (lncRNAs) are emerging as new players in gene regulation, but how lncRNAs …
Reversal of obesity by targeted ablation of adipose tissue
Obesity is an increasingly prevalent human condition in developed societies. Despite major
progress in the understanding of the molecular mechanisms leading to obesity, no safe and …
progress in the understanding of the molecular mechanisms leading to obesity, no safe and …
Prohibitins control cell proliferation and apoptosis by regulating OPA1-dependent cristae morphogenesis in mitochondria
C Merkwirth, S Dargazanli, T Tatsuta… - Genes & …, 2008 - genesdev.cshlp.org
Prohibitins comprise an evolutionarily conserved and ubiquitously expressed family of
membrane proteins with poorly described functions. Large assemblies of PHB1 and PHB2 …
membrane proteins with poorly described functions. Large assemblies of PHB1 and PHB2 …
[HTML][HTML] Prohibitin function within mitochondria: essential roles for cell proliferation and cristae morphogenesis
Prohibitins comprise an evolutionary conserved and ubiquitously expressed family of
membrane proteins. Various roles in different cellular compartments have been proposed for …
membrane proteins. Various roles in different cellular compartments have been proposed for …
Prohibitin induces the transcriptional activity of p53 and is exported from the nucleus upon apoptotic signaling
Prohibitin, a potential tumor suppressor protein, has been shown to inhibit cell proliferation
and repress E2F transcriptional activity. Though prohibitin has potent transcriptional …
and repress E2F transcriptional activity. Though prohibitin has potent transcriptional …
Formation of membrane-bound ring complexes by prohibitins in mitochondria
T Tatsuta, K Model, T Langer - Molecular biology of the cell, 2005 - Am Soc Cell Biol
Prohibitins comprise a remarkably conserved protein family in eukaryotic cells with
proposed functions in cell cycle progression, senescence, apoptosis, and the regulation of …
proposed functions in cell cycle progression, senescence, apoptosis, and the regulation of …
Prohibitins and the functional compartmentalization of mitochondrial membranes
Prohibitins constitute an evolutionarily conserved and ubiquitously expressed family of
membrane proteins that are essential for cell proliferation and development in higher …
membrane proteins that are essential for cell proliferation and development in higher …