Increasing evidence suggests that renal inflammation contributes to the pathogenesis and
progression of diabetic kidney disease (DKD) and that anti-inflammatory therapies might …

Quantitative gene expression analysis in renal biopsies: A novel protocol for a high-
throughput multicenter application. Background Recent advances in gene expression …

Thrombin is a procoagulant and proinflammatory molecule in vivo. In vitro, thrombin has
been shown to induce endothelial activation, notably IL-8 secretion and adhesion molecule …

Plasminogen activator inhibitor-1 (PAI-1) is a serine protease inhibitor that was isolated 20
years ago. First recognized as an inhibitor of intravascular fibrinolysis, it is now evident that …

A role of coagulation proteases in kidney disease beyond their function in normal
haemostasis and thrombosis has long been suspected, and studies performed in the past 15 …

Protease-activated receptor (PAR)-1 is a cellular receptor for thrombin that is activated after
proteolytic cleavage. The contribution of PAR-1 to inflammatory cell–mediated renal injury …

Background Excessive anticoagulation with warfarin can result in acute kidney injury (AKI)
by causing glomerular hemorrhage and renal tubular obstruction by red blood cell (RBC) …

The deleterious role of fibrin deposition in arthritic joints prompted us to explore the effect of
the thrombin inhibition on the course of collagen-induced arthritis (CIA) in the mouse. CIA …

Endothelial cells of the kidney vasa recta express the urea transporter HUT11. The cell
specific expression of the human urea transporter HUT11 in human and rat kidneys was …

Fibrosis, also known as organ scarring, describes a pathological stiffening of organs or
tissues caused by increased synthesis of extracellular matrix (ECM) components. In the past …