Abstract Information storage and retrieval is essential for all life. In biology, information is
primarily stored in two distinct ways: the genome, comprising nucleic acids, acts as a …

Aging, as a complex process involving multiple cellular and molecular pathways, is known to
be exacerbated by various stresses. Because responses to these stresses, such as oxidative …

Epigenetic dysregulation emerges as a critical hallmark and driving force of aging. Although
still an evolving field with much to explore, it has rapidly gained significance by providing …

The inexorability of the aging process has sparked the curiosity of human beings since
ancient times. However, despite this interest and the extraordinary scientific advances in the …

Increasing evidence has revealed that cellular senescence drives NDs, including
Alzheimer's disease (AD) and Parkinson's disease. Different senescent cell populations …

To systematically characterize the loss of tissue integrity and organ dysfunction resulting
from aging, we produced an in-depth spatial transcriptomic profile of nine tissues in male …

Age-related changes in DNA methylation (DNAm) form the basis of the most robust
predictors of age—epigenetic clocks—but a clear mechanistic understanding of exactly …

Young blood plasma is known to confer beneficial effects on various organs in mice and
rats. However, it was not known whether plasma from young adult pigs rejuvenates old rat …

Aging involves seemingly paradoxical changes in energy metabolism. Molecular damage
accumulation increases cellular energy expenditure, yet whole-body energy expenditure …

The intricate interplay between cellular senescence and alterations in the gut microbiome
emerges as a pivotal axis in the aging process, increasingly recognized for its contribution to …