The many actions of insulin in skeletal muscle, the paramount tissue determining glycemia
As the principal tissue for insulin-stimulated glucose disposal, skeletal muscle is a primary
driver of whole-body glycemic control. Skeletal muscle also uniquely responds to muscle …
driver of whole-body glycemic control. Skeletal muscle also uniquely responds to muscle …
Insulin signalling and GLUT4 trafficking in insulin resistance
J van Gerwen, AS Shun-Shion… - Biochemical Society …, 2023 - portlandpress.com
Insulin-stimulated glucose uptake into muscle and adipose tissue is vital for maintaining
whole-body glucose homeostasis. Insulin promotes glucose uptake into these tissues by …
whole-body glucose homeostasis. Insulin promotes glucose uptake into these tissues by …
Palmitic acid control of ciliogenesis modulates insulin signaling in hypothalamic neurons through an autophagy-dependent mechanism
Palmitic acid (PA) is significantly increased in the hypothalamus of mice, when fed
chronically with a high-fat diet (HFD). PA impairs insulin signaling in hypothalamic neurons …
chronically with a high-fat diet (HFD). PA impairs insulin signaling in hypothalamic neurons …
The evolving view of thermogenic fat and its implications in cancer and metabolic diseases
X Yin, Y Chen, R Ruze, R Xu, J Song… - Signal Transduction and …, 2022 - nature.com
The incidence of metabolism-related diseases like obesity and type 2 diabetes mellitus has
reached pandemic levels worldwide and increased gradually. Most of them are listed on the …
reached pandemic levels worldwide and increased gradually. Most of them are listed on the …
GLUT4 On the move
Insulin rapidly stimulates GLUT4 translocation and glucose transport in fat and muscle cells.
Signals from the occupied insulin receptor are translated into downstream signalling …
Signals from the occupied insulin receptor are translated into downstream signalling …
Lysosomal trafficking of the glucose transporter GLUT1 requires sequential regulation by TXNIP and ubiquitin
SJ Qualls-Histed, CP Nielsen, JA MacGurn - Iscience, 2023 - cell.com
Glucose transporters are gatekeepers of cellular glucose metabolism. Understanding how
their activity is regulated can provide insight into mechanisms of glucose homeostasis and …
their activity is regulated can provide insight into mechanisms of glucose homeostasis and …
Aerobic exercise-induced decrease of chemerin improved glucose and lipid metabolism and fatty liver of diabetes mice through key metabolism enzymes and proteins
X Lin, J Qu, L Yin, R Wang, X Wang - … (BBA)-Molecular and Cell Biology of …, 2023 - Elsevier
Our previous studies have implicated an important role of adipokine chemerin in exercise-
induced improvements of glycolipid metabolism and fatty liver in diabetes rat, but the …
induced improvements of glycolipid metabolism and fatty liver in diabetes rat, but the …
Microtubule-mediated GLUT4 trafficking is disrupted in insulin-resistant skeletal muscle
Microtubules serve as tracks for long-range intracellular trafficking of glucose transporter 4
(GLUT4), but the role of this process in skeletal muscle and insulin resistance is unclear …
(GLUT4), but the role of this process in skeletal muscle and insulin resistance is unclear …
A high-content endogenous GLUT4 trafficking assay reveals new aspects of adipocyte biology
Insulin-induced GLUT4 translocation to the plasma membrane in muscle and adipocytes is
crucial for whole-body glucose homeostasis. Currently, GLUT4 trafficking assays rely on …
crucial for whole-body glucose homeostasis. Currently, GLUT4 trafficking assays rely on …
The posttranslational regulation of amino acid transporters is critical for their function in the tumor microenvironment
Highlights●Amino acid transporters are an essential component of cell metabolism.●
Posttranslational modifications regulate transporter expression and localization.● …
Posttranslational modifications regulate transporter expression and localization.● …