Introduction Pharmacovigilance studies have definitely established that clozapine can cause
myocarditis. Two published reviews suggested that on rare occasions other antipsychotics …

From a systematic review framework, we analysed the clinical evidence on the effectiveness
and safety of monotherapy and combination chemotherapy for Chagas disease (ChD) …

Eugenol is the main constituent of clove extract. It is a remarkably versatile molecule
incorporated as a functional ingredient in several food products and widely applied in the …

Aims From well-delimited immunomodulatory, redox and antimicrobial properties;
metronidazole and eugenol were used as structural platforms to assembly two new …

Psoriasis is an autoimmune, inflammatory and chronic skin disease in which cell growth and
proliferation are increased, causing erythema, lesions and skin's peeling. Oral methotrexate …

Aims The relationship between redox imbalance and cardiovascular senescence in
infectious myocarditis is unknown. Thus, the aim of this study was to investigate whether …

The anti-inflammatory and cardioprotective potential of coumarin metabolites in infectious
myocarditis remains overlooked. Thus, the impact of the synthetic 4-nitrobenzoylcoumarin …

Considering the efficacy of rapamycin in increasing lifespan and healthspan, attenuating the
aging-dependent immunological decline, we compared the evolution of Trypanosoma cruzi …

Phenothiazines inhibit antioxidant enzymes in trypanosomatids. However, potential
interferences with host cell antioxidant defenses are central concerns in using these drugs to …

Although renin-angiotensin system (RAS) imbalance is manifested in cardiomyopathies with
different etiologies, the impact of RAS effectors on Chagas cardiomyopathy and skeletal …