Retinal neurodegenerative diseases like age-related macular degeneration, glaucoma,
diabetic retinopathy and retinitis pigmentosa each have a different etiology and …

Autophagy is a catabolic pathway that promotes the degradation and recycling of cellular
components. Proteins, lipids, and even whole organelles are engulfed in autophagosomes …

Retinitis pigmentosa is an incurable retinal disease that leads to blindness. One puzzling
aspect concerns the progression of the disease. Although most mutations that cause retinitis …

Photoreceptor cell death is the major hallmark of a group of human inherited retinal
degenerations commonly referred to as retinitis pigmentosa (RP). Although the causative …

Aging contributes to the appearance of several retinopathies and is the largest risk factor for
aged‐related macular degeneration, major cause of blindness in the elderly population …

Mitochondrial autophagy, also known as mitophagy, is an autophagosome-based
mitochondrial degradation process that eliminates unwanted or damaged mitochondria after …

Inherited retinal dystrophies (IRDs) are a large group of genetically and clinically
heterogeneous diseases characterized by the progressive degeneration of the retina …

Chaperone-mediated autophagy activity, essential in the cellular defense against
proteotoxicity, declines with age, and preventing this decline in experimental genetic models …

Retinitis pigmentosa is a group of hereditary retinal dystrophies that normally result in
photoreceptor cell death and vision loss both in animal models and in affected patients. The …

Autophagy is a fundamental homeostatic pathway that mediates the degradation and
recycling of intracellular components. It serves as a key quality control mechanism …