Hepatocellular carcinoma (HCC) is a complex biological process and is often diagnosed at
advanced stages with no effective treatment options. With advances in tumor biology and …

Ubiquitin is the founding member of a family of structurally conserved proteins that regulate
a host of processes in eukaryotic cells. Ubiquitin and its relatives carry out their functions …

Hepatocellular carcinoma (HCC) is a leading cause of cancer mortality and has an
increasing incidence worldwide. HCC can be induced by multiple etiologies, is influenced …

The protein inhibitor of activated STAT (PIAS) family of proteins has been proposed to
regulate the activity of many transcription factors, including signal transducer and activator of …

Hypoxia is a common pathophysiological occurrence with a profound impact on the cellular
transcriptome. The consequences of hypoxia-induced or hypoxia-repressed gene …

Introduction p53 protein was first identified in 1979 as a transformation-related protein [1]
and a cellular protein which accumulates in the nuclei of cancer cells and binds tightly to the …

Abstract MDM2, a ubiquitin E3-ligase of the RING family, has a key role in regulating p53
abundance. During normal non-stress conditions p53 is targeted for degradation by MDM2 …

Hepatocellular carcinoma is often diagnosed at an advanced stage, when it is not amenable
to curative therapies. There is no effective chemotherapy. Advances in cancer biology …

Neurons are exposed to high levels of DNA damage from both physiological and
pathological sources. Neurons are post-mitotic and their loss cannot be easily recovered …

Herpesvirus-associated ubiquitin-specific protease (HAUSP, also known as USP7), a
deubiquitylating enzyme of the ubiquitin-specific processing protease family, specifically …