Neonatal hypoxia-ischaemia (HI) is the most common cause of death and disability in
human neonates, and is often associated with persistent motor, sensory, and cognitive …

Objective To establish the evidence of therapeutic hypothermia for newborns with hypoxic
ischemic encephalopathy (HIE). Data Sources Cochrane Central Register of Controlled …

Background Whether hypothermic therapy improves neurodevelopmental outcomes in
newborn infants with asphyxial encephalopathy is uncertain. Methods We performed a …

Background Hypothermia is protective against brain injury after asphyxiation in animal
models. However, the safety and effectiveness of hypothermia in term infants with …

Background Cerebral hypothermia can improve outcome of experimental perinatal hypoxia-
ischaemia. We did a multicentre randomised controlled trial to find out if delayed head …

This article offers the preferred methods and indications for longterm, conventional
electroencephalography (EEG) monitoring for selected, high-risk neonates of postmenstrual …

Background In neonatal encephalopathy, the clinical manifestations of injury can only be
reliably assessed several years after an intervention, complicating early prognostication and …

OBJECTIVE: Mild hypothermia after perinatal hypoxic-ischemic encephalopathy (HIE)
reduces neurologic sequelae without significant adverse effects, but studies are needed to …

Background Moderate hypothermia in neonates with hypoxic–ischaemic encephalopathy
might improve survival and neurological outcomes at up to 18 months of age, although …

Background Moderate cooling after birth asphyxia is associated with substantial reductions
in death and disability, but additional therapies might provide further benefit. We assessed …