Stimuli-responsive ferroptosis for cancer therapy
Ferroptosis, an iron-dependent programmed cell death mechanism, is regulated by distinct
molecular pathways of lipid peroxidation caused by intracellular iron supplementation and …
molecular pathways of lipid peroxidation caused by intracellular iron supplementation and …
Pericyte control of blood flow across microvascular zones in the central nervous system
DA Hartmann, V Coelho-Santos… - Annual review of …, 2022 - annualreviews.org
The vast majority of the brain's vascular length is composed of capillaries, where our
understanding of blood flow control remains incomplete. This review synthesizes current …
understanding of blood flow control remains incomplete. This review synthesizes current …
Functional ultrasound localization microscopy reveals brain-wide neurovascular activity on a microscopic scale
The advent of neuroimaging has increased our understanding of brain function. While most
brain-wide functional imaging modalities exploit neurovascular coupling to map brain …
brain-wide functional imaging modalities exploit neurovascular coupling to map brain …
The neurovasculome: key roles in brain health and cognitive impairment: a scientific statement from the American Heart Association/American Stroke Association
Background: Preservation of brain health has emerged as a leading public health priority for
the aging world population. Advances in neurovascular biology have revealed an intricate …
the aging world population. Advances in neurovascular biology have revealed an intricate …
Non-invasive temporal interference electrical stimulation of the human hippocampus
Deep brain stimulation (DBS) via implanted electrodes is used worldwide to treat patients
with severe neurological and psychiatric disorders. However, its invasiveness precludes …
with severe neurological and psychiatric disorders. However, its invasiveness precludes …
Neurovascular coupling: motive unknown
PJ Drew - Trends in neurosciences, 2022 - cell.com
In the brain, increases in neural activity drive changes in local blood flow via neurovascular
coupling. The common explanation for increased blood flow (known as functional …
coupling. The common explanation for increased blood flow (known as functional …
Pericyte remodeling is deficient in the aged brain and contributes to impaired capillary flow and structure
Deterioration of brain capillary flow and architecture is a hallmark of aging and dementia. It
remains unclear how loss of brain pericytes in these conditions contributes to capillary …
remains unclear how loss of brain pericytes in these conditions contributes to capillary …
Hippocampal vascular supply and its role in vascular cognitive impairment
AC Johnson - Stroke, 2023 - Am Heart Assoc
The incidence of age-related dementia is increasing as the world population ages and due
to lack of effective treatments for dementia. Vascular contributions to cognitive impairment …
to lack of effective treatments for dementia. Vascular contributions to cognitive impairment …
The CLDN5 gene at the blood-brain barrier in health and disease
Y Hashimoto, C Greene, A Munnich… - Fluids and Barriers of the …, 2023 - Springer
The CLDN5 gene encodes claudin-5 (CLDN-5) that is expressed in endothelial cells and
forms tight junctions which limit the passive diffusions of ions and solutes. The blood–brain …
forms tight junctions which limit the passive diffusions of ions and solutes. The blood–brain …
[HTML][HTML] Direct vascular contact is a hallmark of cerebral astrocytes
L Hösli, M Zuend, G Bredell, HS Zanker… - Cell reports, 2022 - cell.com
Astrocytes establish extensive networks via gap junctions that allow each astrocyte to
connect indirectly to the vasculature. However, the proportion of astrocytes directly …
connect indirectly to the vasculature. However, the proportion of astrocytes directly …