Glycolysis inhibition for anticancer treatment

H Pelicano, DS Martin, RH Xu, P Huang - Oncogene, 2006 - nature.com
Most cancer cells exhibit increased glycolysis and use this metabolic pathway for generation
of ATP as a main source of their energy supply. This phenomenon is known as the Warburg …

Mitochondrial functionality in male fertility: from spermatogenesis to fertilization

YJ Park, MG Pang - Antioxidants, 2021 - mdpi.com
Mitochondria are structurally and functionally distinct organelles that produce adenosine
triphosphate (ATP) through oxidative phosphorylation (OXPHOS), to provide energy to …

Mitochondria functionality and sperm quality

A Amaral, B Lourenço, M Marques… - …, 2013 - rep.bioscientifica.com
Although mitochondria are best known for being the eukaryotic cell powerhouses, these
organelles participate in various cellular functions besides ATP production, such as calcium …

Significance of mitochondrial reactive oxygen species in the generation of oxidative stress in spermatozoa

AJ Koppers, GN De Iuliis, JM Finnie… - The Journal of …, 2008 - academic.oup.com
Context: Male infertility has been linked with the excessive generation of reactive oxygen
species (ROS) by defective spermatozoa. However, the subcellular origins of this activity are …

Mitochondria: their role in spermatozoa and in male infertility

M Boguenet, PE Bouet, A Spiers… - Human …, 2021 - academic.oup.com
BACKGROUND The best-known role of spermatozoa is to fertilize the oocyte and to transmit
the paternal genome to offspring. These highly specialized cells have a unique structure …

The role of mitochondria in energy production for human sperm motility

P Piomboni, R Focarelli, A Stendardi… - … journal of andrology, 2012 - Wiley Online Library
Mitochondria of spermatozoa are different from the corresponding organelles of somatic
cells, in both their morphology and biochemistry. The biochemical differences are essentially …

Oxidative phosphorylation versus glycolysis: what fuel do spermatozoa use?

SS du Plessis, A Agarwal, G Mohanty… - Asian journal of …, 2015 - journals.lww.com
Spermatozoa are highly specialized cells. Adenosine triphosphate (ATP), which provides
the energy for supporting the key functions of the spermatozoa, is formed by 2 metabolic …

Mitochondrial functionality in reproduction: from gonads and gametes to embryos and embryonic stem cells

J Ramalho-Santos, S Varum, S Amaral… - Human reproduction …, 2009 - academic.oup.com
BACKGROUND Mitochondria are multitasking organelles involved in ATP synthesis,
reactive oxygen species (ROS) production, calcium signalling and apoptosis; and …

The effects of diabetes on male fertility and epigenetic regulation during spermatogenesis

GL Ding, Y Liu, ME Liu, JX Pan, MX Guo… - Asian journal of …, 2015 - journals.lww.com
The effects of diabetes mellitus include long-term damages, dysfunctions, and failures of
various organs. An important complication of diabetes is the disturbance in the male …

Adenylate kinase and AMP signaling networks: metabolic monitoring, signal communication and body energy sensing

P Dzeja, A Terzic - International journal of molecular sciences, 2009 - mdpi.com
Adenylate kinase and downstream AMP signaling is an integrated metabolic monitoring
system which reads the cellular energy state in order to tune and report signals to metabolic …