Shared and independent roles of CGRP and PACAP in migraine pathophysiology

A Kuburas, AF Russo - The Journal of Headache and Pain, 2023 - Springer
The neuropeptides calcitonin gene-related peptide (CGRP) and pituitary adenylate cyclase-
activating polypeptide (PACAP) have emerged as mediators of migraine pathogenesis. Both …

Involvement of the cerebellum in migraine

M Wang, JO Tutt, NO Dorricott, KL Parker… - Frontiers in systems …, 2022 - frontiersin.org
Migraine is a disabling neurological disease characterized by moderate or severe
headaches and accompanied by sensory abnormalities, eg, photophobia, allodynia, and …

Advances in understanding migraine pathophysiology: a bench to bedside review of research insights and therapeutics

K Frimpong-Manson, YT Ortiz, LR McMahon… - Frontiers in Molecular …, 2024 - frontiersin.org
The individual and global burden of migraine is of such significance that there are
accelerated efforts to develop new therapies. New migraine therapeutics are needed to …

[HTML][HTML] Stimulation of CGRP-expressing neurons in the medial cerebellar nucleus induces light and touch sensitivity in mice

M Wang, WC Castonguay, TL Duong, MW Huebner… - Neurobiology of Pain, 2022 - Elsevier
Calcitonin gene-related peptide (CGRP) is considered a major player in migraine
pathophysiology. However, the location and mechanisms of CGRP actions in migraine are …

Both systemic Calcitonin Gene Related Peptide (CGRP) and a vestibular challenge promote anxiety-related behaviors and dynamic imbalance in mice

SM Rahman, C Hauser, S Faucher, E Fine, AE Luebke - bioRxiv, 2023 - biorxiv.org
Motion-induced anxiety and agoraphobia are more frequent symptoms in patients with
vestibular migraine than migraine without vertigo. The neuropeptide calcitonin gene-related …

Loss of calcitonin gene-related peptide (αCGRP) and use of a vestibular challenge highlight balance deficiencies in aging mice

SM Rahman, C Hauser, AE Luebke - Plos one, 2024 - journals.plos.org
Aging impacts the vestibular system and contributes to imbalance. In fact, imbalance
precedes changes in cognition in the elderly. However, research is limited in assessing …

A new vision of the role of the cerebellum in pain processing

JM Prati, AC Gianlorenço - Journal of Neural Transmission, 2025 - Springer
The cerebellum is a structure in the suprasegmental nervous system classically known for its
involvement in motor functions such as motor planning, coordination, and motor learning …

[HTML][HTML] Potential neural mechanisms of acupuncture therapy on migraine: a systematic review and activation likelihood estimation meta-analysis update

M Qi, Y Wang, Y Zhang, Y Feng… - Quantitative Imaging in …, 2025 - qims.amegroups.org
Background: Migraine is a common, disabling, chronic headache disorder. Acupuncture is
one of the effective complementary therapies for migraine. However, the neural mechanisms …

A vestibular challenge combined with calcitonin gene-related peptide (CGRP) promotes anxiety-like behaviors

SM Rahman, C Hauser, S Faucher, E Fine, AE Luebke - eneuro, 2024 - eneuro.org
Motion-induced anxiety and agoraphobia are more frequent symptoms in patients with
vestibular migraine (VM) than migraine without vertigo. The neuropeptide calcitonin gene …

Calcitonin gene-related peptide receptor antagonism reduces motion sickness indicators in mouse migraine models

SM Rahman, AE Luebke - Cephalalgia, 2024 - journals.sagepub.com
Background Migraine and vestibular migraine are disorders associated with a heightened
motion sensitivity that provoke symptoms of motion-induced nausea and motion sickness …