Shared and independent roles of CGRP and PACAP in migraine pathophysiology
A Kuburas, AF Russo - The Journal of Headache and Pain, 2023 - Springer
The neuropeptides calcitonin gene-related peptide (CGRP) and pituitary adenylate cyclase-
activating polypeptide (PACAP) have emerged as mediators of migraine pathogenesis. Both …
activating polypeptide (PACAP) have emerged as mediators of migraine pathogenesis. Both …
Involvement of the cerebellum in migraine
Migraine is a disabling neurological disease characterized by moderate or severe
headaches and accompanied by sensory abnormalities, eg, photophobia, allodynia, and …
headaches and accompanied by sensory abnormalities, eg, photophobia, allodynia, and …
Advances in understanding migraine pathophysiology: a bench to bedside review of research insights and therapeutics
The individual and global burden of migraine is of such significance that there are
accelerated efforts to develop new therapies. New migraine therapeutics are needed to …
accelerated efforts to develop new therapies. New migraine therapeutics are needed to …
[HTML][HTML] Stimulation of CGRP-expressing neurons in the medial cerebellar nucleus induces light and touch sensitivity in mice
M Wang, WC Castonguay, TL Duong, MW Huebner… - Neurobiology of Pain, 2022 - Elsevier
Calcitonin gene-related peptide (CGRP) is considered a major player in migraine
pathophysiology. However, the location and mechanisms of CGRP actions in migraine are …
pathophysiology. However, the location and mechanisms of CGRP actions in migraine are …
Both systemic Calcitonin Gene Related Peptide (CGRP) and a vestibular challenge promote anxiety-related behaviors and dynamic imbalance in mice
SM Rahman, C Hauser, S Faucher, E Fine, AE Luebke - bioRxiv, 2023 - biorxiv.org
Motion-induced anxiety and agoraphobia are more frequent symptoms in patients with
vestibular migraine than migraine without vertigo. The neuropeptide calcitonin gene-related …
vestibular migraine than migraine without vertigo. The neuropeptide calcitonin gene-related …
Loss of calcitonin gene-related peptide (αCGRP) and use of a vestibular challenge highlight balance deficiencies in aging mice
SM Rahman, C Hauser, AE Luebke - Plos one, 2024 - journals.plos.org
Aging impacts the vestibular system and contributes to imbalance. In fact, imbalance
precedes changes in cognition in the elderly. However, research is limited in assessing …
precedes changes in cognition in the elderly. However, research is limited in assessing …
A new vision of the role of the cerebellum in pain processing
JM Prati, AC Gianlorenço - Journal of Neural Transmission, 2025 - Springer
The cerebellum is a structure in the suprasegmental nervous system classically known for its
involvement in motor functions such as motor planning, coordination, and motor learning …
involvement in motor functions such as motor planning, coordination, and motor learning …
[HTML][HTML] Potential neural mechanisms of acupuncture therapy on migraine: a systematic review and activation likelihood estimation meta-analysis update
M Qi, Y Wang, Y Zhang, Y Feng… - Quantitative Imaging in …, 2025 - qims.amegroups.org
Background: Migraine is a common, disabling, chronic headache disorder. Acupuncture is
one of the effective complementary therapies for migraine. However, the neural mechanisms …
one of the effective complementary therapies for migraine. However, the neural mechanisms …
A vestibular challenge combined with calcitonin gene-related peptide (CGRP) promotes anxiety-like behaviors
SM Rahman, C Hauser, S Faucher, E Fine, AE Luebke - eneuro, 2024 - eneuro.org
Motion-induced anxiety and agoraphobia are more frequent symptoms in patients with
vestibular migraine (VM) than migraine without vertigo. The neuropeptide calcitonin gene …
vestibular migraine (VM) than migraine without vertigo. The neuropeptide calcitonin gene …
Calcitonin gene-related peptide receptor antagonism reduces motion sickness indicators in mouse migraine models
SM Rahman, AE Luebke - Cephalalgia, 2024 - journals.sagepub.com
Background Migraine and vestibular migraine are disorders associated with a heightened
motion sensitivity that provoke symptoms of motion-induced nausea and motion sickness …
motion sensitivity that provoke symptoms of motion-induced nausea and motion sickness …