Metabolic biomarker profiling for identification of susceptibility to severe pneumonia and COVID-19 in the general population

H Julkunen, A Cichońska, PE Slagboom, P Würtz… - elife, 2021‏ - elifesciences.org
Biomarkers of low-grade inflammation have been associated with susceptibility to a severe
infectious disease course, even when measured prior to disease onset. We investigated …

Leptin alters energy intake and fat mass but not energy expenditure in lean subjects

P Chrysafi, N Perakakis, OM Farr, K Stefanakis… - Nature …, 2020‏ - nature.com
Based on studies in mice, leptin was expected to decrease body weight in obese
individuals. However, the majority of the obese are hyperleptinemic and do not respond to …

Apt interpretation of comprehensive lipoprotein data in large-scale epidemiology: disclosure of fundamental structural and metabolic relationships

M Ala-Korpela, S Zhao, MR Järvelin… - International Journal …, 2022‏ - academic.oup.com
Background Quantitative lipoprotein analytics using nuclear magnetic resonance (NMR)
spectroscopy is currently commonplace in large-scale studies. One methodology has …

Understanding protection from SARS-CoV-2 using metabolomics

E Barberis, E Amede, M Tavecchia, E Marengo… - Scientific Reports, 2021‏ - nature.com
The COVID-19 pandemic is still raging in most countries. Although the recent mass
vaccination campaign has opened a new chapter in the battle against SARS-CoV-2, the …

Effect of delayed centrifugation on the levels of NMR-measured lipoproteins and metabolites in plasma and Serum samples

J Debik, SH Isaksen, M Strømmen, M Spraul… - Analytical …, 2022‏ - ACS Publications
Metabolic profiling is widely used for large-scale association studies, based on biobank
material. The main obstacle to the translation of metabolomic findings into clinical …

Metabolic and immune markers for precise monitoring of COVID-19 severity and treatment

AF Rendeiro, CK Vorkas, J Krumsiek… - Frontiers in …, 2022‏ - frontiersin.org
Deep understanding of the SARS-CoV-2 effects on host molecular pathways is paramount
for the discovery of early biomarkers of outcome of coronavirus disease 2019 (COVID-19) …

[HTML][HTML] Heme oxygenase-1 and blood bilirubin are gradually activated by oral d-glyceric acid

OP Hirvonen, M Lehti, H Kyröläinen, H Kainulainen - Antioxidants, 2022‏ - mdpi.com
It has been shown that small doses of oral D-glyceric acid (DGA) activate mitochondrial
metabolism and reduce inflammation among 50–60-year-old healthy volunteers. The …

The metabolic fingerprint of COVID-19 severity

T Dierckx, J Van Elslande, H Salmela, B Decru… - MedRxiv, 2020‏ - medrxiv.org
Abstract Corona virus disease 2019 (COVID-19) has been associated with a wide range of
divergent pathologies, and risk of severe disease is reported to be increased by a similarly …

A machine learning PROGRAM to identify COVID-19 and other diseases from hematology data

PA Gladding, Z Ayar, K Smith, P Patel, J Pearce… - Future science …, 2021‏ - Taylor & Francis
Aim: We propose a method for screening full blood count metadata for evidence of
communicable and noncommunicable diseases using machine learning (ML). Materials & …

[PDF][PDF] Apt interpretation of comprehensive lipoprotein data in large-scale epidemiology–disclosure of fundamental structural and metabolic relationships

VP Mäkinen, P Ohukainen‏ - scholar.archive.org
Aims Quantitative lipoprotein analytics by NMR spectroscopy is currently commonplace in
largescale studies. One methodology has become widespread and is currently being …