Myasthenia gravis: epidemiology, pathophysiology and clinical manifestations

L Dresser, R Wlodarski, K Rezania… - Journal of clinical medicine, 2021 - mdpi.com
Myasthenia gravis (MG) is an autoimmune neurological disorder characterized by defective
transmission at the neuromuscular junction. The incidence of the disease is 4.1 to 30 cases …

Anatomy of the antigenic structure of a large memberane autoantigen, the muscle‐type nicotinic acetylcholine receptor

SJ Tzartos, T Barkas, MT Cung… - Immunological …, 1998 - Wiley Online Library
The neuromuscular junction nicotinic acetylcholine receptor (AChR), a pentameric
membrane glycoprotein, is the autoantigen involved in the autoimmune disease myasthenia …

A sequence pattern common to T cell epitopes.

JB Rothbard, WR Taylor - The EMBO journal, 1988 - embopress.org
An analysis of the known cytotoxic and helper T cell epitopes has revealed similarity within
their primary sequences. These similar motifs, characteristic of the known determinants …

Clinical correlations of antibodies that bind, block, or modulate human acetylcholine receptors in myasthenia gravis.

FM Howard Jr, VA Lennon, JON Finley… - Annals of the New …, 1987 - europepmc.org
Acetylcholine receptor (AChR) binding and AChR modulating antibodies were found with
approximately the same frequency (86%) in 349 patients with myasthenia gravis (MG) …

Mechanisms underlying autoimmune synaptic encephalitis leading to disorders of memory, behavior and cognition: insights from molecular, cellular and synaptic …

EH Moscato, A Jain, X Peng, EG Hughes… - European Journal of …, 2010 - Wiley Online Library
Recently, several novel, potentially lethal and treatment‐responsive syndromes that affect
hippocampal and cortical function have been shown to be associated with auto‐antibodies …

Breakdown of tolerance to a self-peptide of acetylcholine receptor α-subunit induces experimental myasthenia gravis in rats

F Baggi, A Annoni, F Ubiali, M Milani… - The Journal of …, 2004 - journals.aai.org
Experimental autoimmune myasthenia gravis (EAMG), a model for human myasthenia (MG),
is routinely induced in susceptible rat strains by a single immunization with Torpedo …

Antibodies against the main immunogenic region of the acetylcholine receptor correlate with disease severity in myasthenia gravis

T Masuda, M Motomura, K Utsugisawa… - Journal of Neurology …, 2012 - jnnp.bmj.com
Objective We developed an assay that detects autoantibodies against the main
immunogenic region (MIR) located at the extracellular end of the nicotinic acetylcholine …

Restricted heterogeneity of T cell receptor transcripts in rheumatoid synovium.

WV Williams, Q Fang, D Demarco… - The Journal of …, 1992 - Am Soc Clin Investig
RA is characterized by massive proliferation of synovial tissue, accompanying infiltration of
the tissue with CD4+ T lymphocytes, and a genetic linkage to the MHC antigen HLA-DR4 …

Cytokines and the pathogenesis of myasthenia gravis

GX Zhang, V Navikas, H Link - … & Nerve: Official Journal of the …, 1997 - Wiley Online Library
Myasthenia gravis (MG) and its animal model experimental autoimmune myasthenia gravis
(EAMG) are caused by autoantibodies against nicotinic acetylcholine receptor (AChR) in …

Both CD4+ and CD8+ T cells are essential to induce experimental autoimmune myasthenia gravis.

GX Zhang, BG **ao, M Bakhiet… - The Journal of …, 1996 - rupress.org
CD4+ T cells have been shown to be crucial in the development of experimental
autoimmune myasthenia gravis (EAMG). The role of CD8+ T cells in EAMG is less well …