The four distinct T-cell antigen receptor polypeptides (α, β, γ, δ) form two different
heterodimers (α: β and γ: δ) that are very similar to immunoglobulins in primary sequence …

T cell receptors (TCRs) are protein complexes formed by six different polypeptides. In most T
cells, TCRs are composed of αβ subunits displaying immunoglobulin-like variable domains …

This standard-setting textbook has defined the field of immunology since 1984, and is now in
its Seventh Edition continuing to deliver the detailed, authoritative, and timely coverage …

The central event in the cellular immune response to invading microorganisms is the specific
recognition of foreign peptides bound to major histocompatibility complex (MHC) molecules …

Abstract Framework monoclonal antibodies have identified a population of human
lymphocytes that express the T3 glycoprotein but not the T-cell receptor (TCR) α-and β …

T-cell receptor α-and β-chain genes were isolated from a class I major histocompatibility
complex-restricted cytotoxic T-cell clone and transferred by protoplast fusion into another …

We have previously described a set of human T-lymphocyte-specific cDNA clones isolated
by a modified differential screening procedure. Apparent full-length cDNAs containing the …

The search for the genes encoding the T-cell receptor α and β chains revealed a third gene,
T γ (ref. 1), which shares with the T α (refs 2–7) and T β (refs 8–15) genes a number of …

▪ Abstract Exciting breakthroughs in the last two years have begun to elucidate the structural
basis of cellular immune recognition. Crystal structures have been determined for full-length …

Experimental allergic encephalomyelitis(EAE) is an induced autoimmune disease mediated
by CD4+ T lymphocytes. Analysis of T cell receptors of myelin basic protein-specific …