Leptospira: the dawn of the molecular genetics era for an emerging zoonotic pathogen

AI Ko, C Goarant, M Picardeau - Nature Reviews Microbiology, 2009 - nature.com
Leptospirosis is a zoonotic disease that has emerged as an important cause of morbidity
and mortality among impoverished populations. One hundred years after the discovery of …

Leptospira as an Emerging Pathogen: A Review of its Biology, Pathogenesis and Host Immune Responses

KV Evangelista, J Coburn - Future microbiology, 2010 - Taylor & Francis
Leptospirosis, the most widespread zoonosis in the world, is an emerging public health
problem, particularly in large urban centers of develo** countries. Several pathogenic …

What Makes a Bacterial Species Pathogenic?:Comparative Genomic Analysis of the Genus Leptospira

DE Fouts, MA Matthias, H Adhikarla… - PLoS neglected …, 2016 - journals.plos.org
Leptospirosis, caused by spirochetes of the genus Leptospira, is a globally widespread,
neglected and emerging zoonotic disease. While whole genome analysis of individual …

Complement control protein factor H: the good, the bad, and the inadequate

VP Ferreira, MK Pangburn, C Cortés - Molecular immunology, 2010 - Elsevier
The complement system is an essential component of the innate immune system that
participates in elimination of pathogens and altered host cells and comprises an essential …

Leptospiral infection, pathogenesis and its diagnosis—A review

AV Samrot, TC Sean, KS Bhavya, CS Sahithya… - Pathogens, 2021 - mdpi.com
Leptospirosis is a perplexing conundrum for many. In the existing literature, the
pathophysiological mechanisms pertaining to leptospirosis is still not understood in full …

Fibronectin: a multidomain host adhesin targeted by bacterial fibronectin-binding proteins

B Henderson, S Nair, J Pallas… - FEMS microbiology …, 2011 - academic.oup.com
Fibronectin, a large and essential multidomain glycoprotein, with multiple adhesive
properties, functioning as a key link between cells and their extracellular matrices, is now …

Hijacking factor H for complement immune evasion

SR Moore, SS Menon, C Cortes… - Frontiers in …, 2021 - frontiersin.org
The complement system is an essential player in innate and adaptive immunity. It consists of
three pathways (alternative, classical, and lectin) that initiate either spontaneously …

[HTML][HTML] Complement factor H related proteins (CFHRs)

C Skerka, Q Chen, V Fremeaux-Bacchi… - Molecular …, 2013 - Elsevier
Factor H related proteins comprise a group of five plasma proteins: CFHR1, CFHR2,
CFHR3, CFHR4 and CFHR5, and each member of this group binds to the central …

Genome reduction in Leptospira borgpetersenii reflects limited transmission potential

DM Bulach, RL Zuerner, P Wilson… - Proceedings of the …, 2006 - National Acad Sciences
Leptospirosis is one of the most common zoonotic diseases in the world, resulting in high
morbidity and mortality in humans and affecting global livestock production. Most infections …

Genome Sequence of the Saprophyte Leptospira biflexa Provides Insights into the Evolution of Leptospira and the Pathogenesis of Leptospirosis

M Picardeau, DM Bulach, C Bouchier, RL Zuerner… - PloS one, 2008 - journals.plos.org
Leptospira biflexa is a free-living saprophytic spirochete present in aquatic environments.
We determined the genome sequence of L. biflexa, making it the first saprophytic Leptospira …