Intense efforts to detect, diagnose, and analyze the kinetic and structural properties of
amyloid fibrils have generated a powerful toolkit of amyloid-specific molecular probes. Since …

We review the present status of experiments and calculations for circularly polarized
luminescence (CPL) of simple organic molecules and of stimuli‐responsive organic …

High-fidelity map** of amyloid-β (Aβ) plaques is critical for the early detection of
Alzheimer's disease. However, in vivo probing of Aβ plaques by commercially available …

Because understanding amyloid fibrillation in molecular detail is essential for development
of strategies to control amyloid formation and overcome neurodegenerative disorders …

The small molecule thioflavin T (ThT) is a defining probe for the identification and
mechanistic study of amyloid fiber formation. As such, ThT is fundamental to investigations of …

A number of small organic molecules have been developed that bind to amyloid fibrils, a
subset of which also inhibit fibrillization. Among these, the benzothiol dye Thioflavin-T (ThT) …

Thioflavin T (ThT), a benzothiazole-based fluorophore, is a prominent dye widely employed
for monitoring amyloid fibril assembly. Despite the near-universal presumption that ThT …

Alzheimer's disease is the most common form of age-related neurodegenerative dementia.
The disease is characterised by the presence of plaques in the cerebral cortex. The major …

The unique enhanced sensitivity of vibrational circular dichroism (VCD) to the formation and
development of amyloid fibrils in solution is extended to four additional fibril-forming proteins …

Water-soluble, long wavelength fluorescent aggregation-induced emission (AIE)-active
materials are in great demand for high contrast biosensing and bioimaging. The substitution …