Antimicrobial peptides (AMPs): A promising class of antimicrobial compounds

M Erdem Büyükkiraz, Z Kesmen - Journal of applied …, 2022 - academic.oup.com
Antimicrobial peptides (AMPs) are compounds, which have inhibitory activity against
microorganisms. In the last decades, AMPs have become powerful alternative agents that …

Advancements in antimicrobial nanoscale materials and self-assembling systems

JA Doolan, GT Williams, KLF Hilton… - Chemical Society …, 2022 - pubs.rsc.org
Antimicrobial resistance is directly responsible for more deaths per year than either
HIV/AIDS or malaria and is predicted to incur a cumulative societal financial burden of at …

Synergistic photothermal antibacterial therapy enabled by multifunctional nanomaterials: Progress and perspectives

X Bai, Y Yang, W Zheng, Y Huang, F Xu… - Materials Chemistry …, 2023 - pubs.rsc.org
In recent years, infection caused by drug-resistant bacteria has become a serious public
health problem. The exploration of antibacterial therapies other than antibiotics has attracted …

Emerging strategies for combating Fusobacterium nucleatum in colorectal cancer treatment: Systematic review, improvements and future challenges

H Liu, Y Yu, A Dong, M Elsabahy, YW Yang… - Exploration, 2024 - Wiley Online Library
Colorectal cancer (CRC) is generally characterized by a high prevalence of Fusobacterium
nucleatum (F. nucleatum), a spindle‐shaped, Gram‐negative anaerobe pathogen derived …

Biotechnological insights on the expression and production of antimicrobial peptides in plants

B Shanmugaraj, CJI Bulaon, A Malla, W Phoolcharoen - Molecules, 2021 - mdpi.com
The emergence of drug-resistant pathogens poses a serious critical threat to global public
health and requires immediate action. Antimicrobial peptides (AMPs) are a class of short …

Physicochemical Features and Peculiarities of Interaction of AMP with the Membrane

M Pirtskhalava, B Vishnepolsky, M Grigolava… - Pharmaceuticals, 2021 - mdpi.com
Antimicrobial peptides (AMPs) are anti-infectives that have the potential to be used as a
novel and untapped class of biotherapeutics. Modes of action of antimicrobial peptides …

Challenge in the discovery of new drugs: antimicrobial peptides against WHO-list of critical and high-priority bacteria

CA Roque-Borda, PB da Silva, MC Rodrigues… - Pharmaceutics, 2021 - mdpi.com
Bacterial resistance has intensified in recent years due to the uncontrolled use of
conventional drugs, and new bacterial strains with multiple resistance have been reported …

[HTML][HTML] How do antimicrobial peptides disrupt the lipopolysaccharide membrane leaflet of Gram-negative bacteria?

H Gong, X Hu, L Zhang, K Fa, M Liao, H Liu… - Journal of Colloid and …, 2023 - Elsevier
Hypothesis: It is widely regarded that antimicrobial peptides (AMPs) kill bacteria by
physically disrupting microbial membranes and causing cytoplasmic leakage, but it remains …

Mechanistic understanding from molecular dynamics in pharmaceutical research 2: lipid membrane in drug design

T Róg, M Girych, A Bunker - Pharmaceuticals, 2021 - mdpi.com
We review the use of molecular dynamics (MD) simulation as a drug design tool in the
context of the role that the lipid membrane can play in drug action, ie, the interaction …

Artificial intelligence-driven antimicrobial peptide discovery

P Szymczak, E Szczurek - Current Opinion in Structural Biology, 2023 - Elsevier
Antimicrobial peptides (AMPs) emerge as promising agents against antimicrobial resistance,
providing an alternative to conventional antibiotics. Artificial intelligence (AI) revolutionized …