Recent total syntheses of fusicoccanes
Y Liu, R Hong - Cell Reports Physical Science, 2024 - cell.com
Fusicoccane diterpenoids, originating from fungi, plants, and bacteria, constitute a diverse
natural product family featuring a 5-8-5 tricyclic framework. They were restricted to plant …
natural product family featuring a 5-8-5 tricyclic framework. They were restricted to plant …
Proteome-scale discovery of protein degradation and stabilization effectors
J Poirson, H Cho, A Dhillon, S Haider, AZ Imrit… - Nature, 2024 - nature.com
Targeted protein degradation and stabilization are promising therapeutic modalities
because of their potency, versatility and their potential to expand the druggable target …
because of their potency, versatility and their potential to expand the druggable target …
Global organelle profiling reveals subcellular localization and remodeling at proteome scale
Defining the subcellular distribution of all human proteins and their remodeling across
cellular states remains a central goal in cell biology. Here, we present a high-resolution …
cellular states remains a central goal in cell biology. Here, we present a high-resolution …
Activation of PPAR-α attenuates myocardial ischemia/reperfusion injury by inhibiting ferroptosis and mitochondrial injury via upregulating 14-3-3η
T Hu, W Yu, X Wang, Z Wang, Z Xu, F Hu, J Liu, F Yu… - Scientific Reports, 2024 - nature.com
This study aimed to explore the effects of peroxisome proliferator-activated receptor α (PPAR-
α), a known inhibitor of ferroptosis, in Myocardial ischemia/reperfusion injury (MIRI) and its …
α), a known inhibitor of ferroptosis, in Myocardial ischemia/reperfusion injury (MIRI) and its …
The subcortical maternal complex modulates the cell cycle during early mammalian embryogenesis via 14-3-3
Z Han, R Wang, P Chi, Z Zhang, L Min, H Jiao… - Nature …, 2024 - nature.com
The subcortical maternal complex (SCMC) is essential for safeguarding female fertility in
mammals. Assembled in oocytes, the SCMC maintains the cleavage of early embryos, but …
mammals. Assembled in oocytes, the SCMC maintains the cleavage of early embryos, but …
[HTML][HTML] Harnessing the 14-3-3 protein–protein interaction network
P Pitasse-Santos, I Hewitt-Richards… - Current Opinion in …, 2024 - Elsevier
Protein–protein interactions (PPIs) play a critical role in cellular signaling and represent
interesting targets for therapeutic intervention. 14-3-3 proteins integrate many signaling …
interesting targets for therapeutic intervention. 14-3-3 proteins integrate many signaling …
Characterizing the protein–protein interaction between MDM2 and 14-3-3σ; proof of concept for small molecule stabilization
JA Ward, B Romartinez-Alonso, DF Kay… - Journal of Biological …, 2024 - ASBMB
Abstract Mouse Double Minute 2 (MDM2) is a key negative regulator of the tumour
suppressor protein p53. MDM2 overexpression occurs in many types of cancer and results …
suppressor protein p53. MDM2 overexpression occurs in many types of cancer and results …
A functional map of the human intrinsically disordered proteome
Intrinsically disordered regions (IDRs) represent at least one-third of the human proteome
and defy the established structure-function paradigm. Because IDRs often have limited …
and defy the established structure-function paradigm. Because IDRs often have limited …
Regulation of lipolysis by 14-3-3 proteins on human adipocyte lipid droplets
Adipocyte lipid droplets (LDs) play a crucial role in systemic lipid metabolism by storing and
releasing lipids to meet the organism's energy needs. Hormonal signals such as …
releasing lipids to meet the organism's energy needs. Hormonal signals such as …
Pathogenic mutations of human phosphorylation sites affect protein–protein interactions
Despite their lack of a defined 3D structure, intrinsically disordered regions (IDRs) of
proteins play important biological roles. Many IDRs contain short linear motifs (SLiMs) that …
proteins play important biological roles. Many IDRs contain short linear motifs (SLiMs) that …