The Hippo–YAP pathway in organ size control and tumorigenesis: an updated version

B Zhao, L Li, Q Lei, KL Guan - Genes & development, 2010 - genesdev.cshlp.org
The Hippo signaling pathway is gaining recognition as an important player in both organ
size control and tumorigenesis, which are physiological and pathological processes that …

The potential role of miRNAs in the pathogenesis of testicular germ cell tumors-A Focus on signaling pathways interplay

AS Doghish, HAM Moustafa, MS Elballal… - … -Research and Practice, 2023 - Elsevier
Testicular germ cell tumors (TGCTs) are the most common testicular neoplasms in
adolescents and young males. Understanding the genetic basis of TGCTs represents a …

[HTML][HTML] Increased serum levels of circulating exosomal microRNA-373 in receptor-negative breast cancer patients

C Eichelser, I Stückrath, V Müller, K Milde-Langosch… - Oncotarget, 2014 - ncbi.nlm.nih.gov
In this study, we compared the blood serum levels of circulating cell-free and exosomal
microRNAs, and their involvement in the molecular subtypes of breast cancer patients. Our …

The LATS1 and LATS2 tumor suppressors: beyond the Hippo pathway

N Furth, Y Aylon - Cell Death & Differentiation, 2017 - nature.com
Proper cellular functionality and homeostasis are maintained by the convergent integration
of various signaling cascades, which enable cells to respond to internal and external …

MicroRNA-520/373 family functions as a tumor suppressor in estrogen receptor negative breast cancer by targeting NF-κB and TGF-β signaling pathways

I Keklikoglou, C Koerner, C Schmidt, JD Zhang… - Oncogene, 2012 - nature.com
MicroRNAs (miRNAs) as modulators of gene expression have been described to display
both tumor-promoting and tumor-suppressive functions. Although their role has been studied …

Epigenetic regulation of the Wnt/β-catenin signaling pathway in cancer

A Sharma, R Mir, S Galande - Frontiers in genetics, 2021 - frontiersin.org
Studies over the past four decades have elucidated the role of Wnt/β-catenin mediated
regulation in cell proliferation, differentiation and migration. These processes are …

A review of currently identified small molecule modulators of microRNA function

EN Van Meter, JA Onyango, KA Teske - European journal of medicinal …, 2020 - Elsevier
Abstract microRNAs are small, noncoding RNA that negatively regulate gene expression.
Since their discovery in 1993, approximately 2500 human mature microRNAs have been …

MicroRNAs in pathogenesis, diagnosis, and treatment of gastroesophageal cancers

JH Song, SJ Meltzer - Gastroenterology, 2012 - Elsevier
The incidence of gastroesophageal cancers is increasing each year, but despite much
research, their molecular mechanisms are incompletely understood. microRNAs (miRNAs) …

Regulation of microRNAs by natural agents: an emerging field in chemoprevention and chemotherapy research

Y Li, D Kong, Z Wang, FH Sarkar - Pharmaceutical research, 2010 - Springer
In recent years, microRNAs have received greater attention in cancer research. These small,
non-coding RNAs could inhibit target gene expression by binding to the 3′ untranslated …

Implication of microRNAs in drug resistance for designing novel cancer therapy

FH Sarkar, Y Li, Z Wang, D Kong, S Ali - Drug resistance updates, 2010 - Elsevier
Recently, microRNAs (miRNAs) have received increasing attention in the field of cancer
research. miRNAs play important roles in many normal biological processes; however, the …