Cells encode information in the sequence of biopolymers, such as nucleic acids, proteins,
and glycans. Although glycans are essential to all living organisms, surprisingly little is …

Small molecule drug discovery has been propelled by the continual development of novel
scientific methodologies to occasion therapeutic advances. Although established …

Peptide sequence analysis using a combination of gas-phase ion/ion chemistry and tandem
mass spectrometry (MS/MS) is demonstrated. Singly charged anthracene anions transfer an …

When non-mass spectrometrists are talking about mass spectrometry it rather often sounds
as if they were telling a story out of Poe's Tales of Mystery and Imagi-tion. Indeed, mass …

Closely related to studying the function of a protein is the analysis of its three‐dimensional
structure and the identification of interaction sites with its binding partners. An alternative …

This tutorial presents the most common ion activation techniques employed in tandem mass
spectrometry. In‐source fragmentation and metastable ion decompositions, as well as the …

Since its introduction, the orbitrap has proven to be a robust mass analyzer that can routinely
deliver high resolving power and mass accuracy. Unlike conventional ion traps such as the …

The analysis of peptides and proteins as well as the grander scope of proteomics (large
scale study of proteins) has been advanced by the development of a versatile array of ion …

The introduction of electron capture dissociation (ECD) to electrospray (ESI) Fourier
transform ion cyclotron resonance mass spectrometry (FT‐ICR MS) constitutes a significant …

This tutorial article introduces mass spectrometry (MS) for peptide fragmentation and protein
identification. The current approaches being used for protein identification include top-down …