The tryptophan catabolite (TRYCAT) pathway is implicated in the pathophysiology of
schizophrenia (SCZ) since the rate-limiting enzyme indoleamine-dioxygenase (IDO) may be …

Precision medicine is rapidly emerging as a strategy to tailor medical treatment to a small
group or even individual patients based on their genetics, environment and lifestyle …

The importance of tryptophan as a precursor for neuroactive compounds has long been
acknowledged. The metabolism of tryptophan along the kynurenine pathway and its …

This review describes the analytical methods that have been developed over the years to
tackle the high polarity and non-chromophoric nature of amino acids (AAs). First, the …

The kynurenine (KYN) pathway is postulated to play various roles in immune system
dysregulation of schizophrenia (SCZ). We conducted a meta-analysis to explore the …

In‐tube solid‐phase microextraction with a capillary column as extraction device can be
directly coupled with high‐performance liquid chromatography systems (HPLC). The in‐tube …

Neurotransmitters are important biological molecules related to several nervous system
diseases (NSDs). Point-of-care testing (POCT) of neurotransmitters is of great importance in …

An ultra-performance liquid chromatography quadrupole time of flight mass spectrometry
(UPLC-qTOF-MS) method using hydrophilic interaction liquid chromatography was …

Branched-chain amino acids (BCAAs) and branched-chain α-keto acids (BCKAs) play
significant biological roles as they are involved in protein and neurotransmitter synthesis as …

This work describes the direct coupling of the in-tube solid-phase microextraction (in-tube
SPME) technique to a tandem mass spectrometry system (MS/MS) to determine amino acids …