Relating sequence encoded information to form and function of intrinsically disordered proteins
Highlights•Compositions of IDPs fall into distinct classes.•Compositional classes encode
preferences for distinct conformational classes.•Functions of disordered proteins are …
preferences for distinct conformational classes.•Functions of disordered proteins are …
Exploring free-energy landscapes of intrinsically disordered proteins at atomic resolution using NMR spectroscopy
The last 15 years have seen a paradigm shift in our understanding of protein biochemistry,
with the realization that an unexpectedly high fraction of the human genome codes for …
with the realization that an unexpectedly high fraction of the human genome codes for …
Develo** a molecular dynamics force field for both folded and disordered protein states
Molecular dynamics (MD) simulation is a valuable tool for characterizing the structural
dynamics of folded proteins and should be similarly applicable to disordered proteins and …
dynamics of folded proteins and should be similarly applicable to disordered proteins and …
Water dispersion interactions strongly influence simulated structural properties of disordered protein states
Many proteins can be partially or completely disordered under physiological conditions.
Structural characterization of these disordered states using experimental methods can be …
Structural characterization of these disordered states using experimental methods can be …
PED in 2021: a major update of the protein ensemble database for intrinsically disordered proteins
Abstract The Protein Ensemble Database (PED)(https://proteinensemble. org), which holds
structural ensembles of intrinsically disordered proteins (IDPs), has been significantly …
structural ensembles of intrinsically disordered proteins (IDPs), has been significantly …
Targeting the disordered C terminus of PTP1B with an allosteric inhibitor
PTP1B, a validated therapeutic target for diabetes and obesity, has a critical positive role in
HER2 signaling in breast tumorigenesis. Efforts to develop therapeutic inhibitors of PTP1B …
HER2 signaling in breast tumorigenesis. Efforts to develop therapeutic inhibitors of PTP1B …
Principles and overview of sampling methods for modeling macromolecular structure and dynamics
Investigation of macromolecular structure and dynamics is fundamental to understanding
how macromolecules carry out their functions in the cell. Significant advances have been …
how macromolecules carry out their functions in the cell. Significant advances have been …
Conformational ensembles of intrinsically disordered proteins and flexible multidomain proteins
Intrinsically disordered proteins (IDPs) and multidomain proteins with flexible linkers show a
high level of structural heterogeneity and are best described by ensembles consisting of …
high level of structural heterogeneity and are best described by ensembles consisting of …
Liquid–liquid phase separation is driven by large-scale conformational unwinding and fluctuations of intrinsically disordered protein molecules
Liquid–liquid phase separation occurs via a multitude of transient, noncovalent, and
intermolecular interactions resulting in phase transition of intrinsically disordered …
intermolecular interactions resulting in phase transition of intrinsically disordered …
Describing intrinsically disordered proteins at atomic resolution by NMR
There is growing interest in the development of physical methods to study the
conformational behaviour and biological activity of intrinsically disordered proteins (IDPs). In …
conformational behaviour and biological activity of intrinsically disordered proteins (IDPs). In …