Lichen metabolites: an overview of some secondary metabolites and their biological potential

M Goga, J Elečko, M Marcinčinová, D Ručová… - Co-evolution of …, 2020 - Springer
Lichens present a symbiotic association between two or more organisms. These unique
organisms produce many chemical compounds, known as secondary metabolites or lichen …

Lichens as a potential natural source of bioactive compounds: a review

V Shukla, GP Joshi, MSM Rawat - Phytochemistry reviews, 2010 - Springer
Biological activity of material whether known in folk medicine or observed in planned
screening program has been the starting point in the drug research. The general pattern is …

Lichens: a promising source of antibiotic and anticancer drugs

G Shrestha, LL St. Clair - Phytochemistry reviews, 2013 - Springer
Lichens are symbiotic associations between fungi and a photosynthetic alga and/or
cyanobacteria. Lichenized fungi have been found to produce a wide array of secondary …

Lichens as a potential source of bioactive secondary metabolites

B Ranković, M Kosanić - Lichen secondary metabolites: bioactive …, 2019 - Springer
Lichens are complex symbiotic associations between fungi and algae which are important
constituents of many ecosystems. The production of various unique extracellular secondary …

Review of the biological properties and toxicity of usnic acid

AAS Araújo, MGD De Melo, TK Rabelo… - Natural product …, 2015 - Taylor & Francis
Since its first isolation in 1844, usnic acid [2, 6-diacetyl-7, 9-dihydroxy-8, 9b-dimethyl-1, 3
(2H, 9bH)-dibenzo-furandione] has become the most extensively studied lichen metabolite …

Variable responses of different human cancer cells to the lichen compounds parietin, atranorin, usnic acid and gyrophoric acid

M Bačkorová, M Bačkor, J Mikeš, R Jendželovský… - Toxicology in vitro, 2011 - Elsevier
One of the ways for searching for potentially new anti-cancer drugs is the testing of various
naturally synthesized compounds. Lichens are a source of unique chemical agents of which …

Lichen secondary metabolites are responsible for induction of apoptosis in HT-29 and A2780 human cancer cell lines

M Bačkorová, R Jendželovský, M Kello, M Bačkor… - Toxicology in vitro, 2012 - Elsevier
Lichens are a known source of approximately 800 unique secondary metabolites, many of
which play important ecological roles, including regulating the equilibrium between …

Cytotoxic Activity and Antioxidant Capacity of Purified Lichen Metabolites: An In Vitro Study

F Brisdelli, M Perilli, D Sellitri, M Piovano… - Phytotherapy …, 2013 - Wiley Online Library
The purpose of this study was to investigate the effects of six lichen metabolites (diffractaic
acid, lobaric acid, usnic acid, vicanicin, variolaric acid, protolichesterinic acid) on …

Bioactive lichen metabolites: alpine habitats as an untapped source

J Boustie, S Tomasi, M Grube - Phytochemistry Reviews, 2011 - Springer
Lichens are fungal and algal/cyanobacterial symbioses resulting in the production of specific
metabolites. Some of these are forming an available biomass for phytochemical …

Usnic acid inhibits breast tumor angiogenesis and growth by suppressing VEGFR2-mediated AKT and ERK1/2 signaling pathways

Y Song, F Dai, D Zhai, Y Dong, J Zhang, B Lu, J Luo… - Angiogenesis, 2012 - Springer
Tumor growth depends on angiogenesis and inducing angiogenesis is one of the most
important hallmarks in the cancer development. Treatment with small molecules that inhibit …