X-ray crystallography is a critical tool in the study of biological systems. It is able to provide
information that has been a prerequisite to understanding the fundamentals of life. It is also a …

Since the process of building and refining a model of a biomacromolecule based on
crystallographic data is subjective, quality-control techniques are required to assess the …

phenix. refine is a program within the PHENIX package that supports crystallographic
structure refinement against experimental data with a wide range of upper resolution limits …

A new software suite, called Crystallography & NMR System (CNS), has been developed for
macromolecular structure determination by X-ray crystallography or solution nuclear …

Structural genomics seeks to expand rapidly the number of protein structures in order to
extract the maximum amount of information from genomic sequence databases. The advent …

Refinement is a process that involves bringing into agreement the structural model,
available prior knowledge and experimental data. To achieve this, the refinement procedure …

Ligand-dependent activation of transcription by nuclear receptors (NRs) is mediated by
interactions with coactivators. Receptor agonists promote coactivator binding, and …

Rifampicin (Rif) is one of the most potent and broad spectrum antibiotics against bacterial
pathogens and is a key component of anti-tuberculosis therapy, stemming from its inhibition …

Chaperonins assist protein folding with the consumption of ATP. They exist as multi-subunit
protein assemblies comprising rings of subunits stacked back to back. In Escherichia coli …

Conformational dynamics play a key role in enzyme catalysis. Although protein motions
have clear implications for ligand flux, a role for dynamics in the chemical step of enzyme …